中国康复理论与实践Issue(1)：1-7,7.DOI:10.3969/j.issn.1006-9771.2016.01.001
早期运动训练对大鼠局灶性脑缺血后运动功能及磁共振弥散张量成像的影响
Effects of Early Exercise on Motor Function and Diffusion Tensor Imaging in Rats after Focal Cerebral Ischemia
摘要
Abstract
Objective To explore the effects of early exercise on motor function and the mechanism in rats after focal cerebral ischemia. Methods 21 Sprague-Dawley male rats were divided into control group (n=7), natural recovery group (n=7) and exercise training group (n=7), and the latter 2 groups were modeled with middle cerebral artery occlusion. The exercise training group received wheel running exercise 24 hours after modeling for 14 days. They were assessed with Rogers score and beam balance test 21 days after modeling. 4 rats in each group received routine MRI and diffusion tensor imaging (DTI) scanning. The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of ischemic (L) and contralateral side (R) were measured, and the rate of them (L/R, r) was calculated. Results There was significant difference in Rogers score among the groups (Z=-0.786, P<0.001), but no significant difference between the natural recovery group and the exercise training group (P>0.05). Beam balance score of the natural recovery group was significantly different from the control group and the exercise training group (F=38.11, P<0.001), but there was no significant difference between the latters (P>0.05). The LFA of the natural recovery group was significantly different from the control group (P<0.05), but not significantly different from the exercise training group (P>0.05);while the rFA of the natural recovery group was significantly different from the control group and the exercise training group (F=19.30, P<0.05). LADC and rADC might be different between the control group and the natural recovery group (P=0.056, P=0.057), but not significantly different between the natural recovery group and the exercise training group (P>0.05). LFA and rFA strongly correlated with all the behavior scores (r=-0.90--0.70, P<0.01); while LADC and rADC moderately correlated with the behavior scores (r=0.50-0.75, P<0.05), except balance (P>0.05). DTT showed that the direction and density of neural fibers were significantly asymmetrical in the natural re-covery group and the exercise training group, and more symmetrical in the exercise training group. Conclusion Early exercise can promote the neural functional recovery in rats after focal cerebral ischemia, which may associate with the improve of conduction of fibers.关键词
脑卒中/脑缺血/运动训练/弥散张量成像/神经纤维/大鼠Key words
stroke/cerebral ischemia/exercise/diffusion tensor imaging/neural fibers/rats分类
医药卫生引用本文复制引用
米海霞,张通,缪培,张玉阁..早期运动训练对大鼠局灶性脑缺血后运动功能及磁共振弥散张量成像的影响[J].中国康复理论与实践,2016,(1):1-7,7.基金项目
“十二五”国家科技支撑计划项目(No.2011BAI08B11)。 （No.2011BAI08B11）
