中国康复理论与实践Issue(1)：8-12,5.DOI:10.3969/j.issn.1006-9771.2016.01.002
运动训练对脑梗死大鼠室管膜下区神经新生的影响
Effect of Wheel Running on Neurogenesis in Subventricular Zone of Adult Rats post Cerebral Ischemia
摘要
Abstract
Objective To observe the effect of wheel running exercise on subventricular zone neurogenesis and the neural function in rats post cerebral ischemia. Methods 48 adult male Sprague-Dawley rats were induced cortical infarcts with left middle artery occlusion and were housed in either standard (control group, n=24) or wheel running (exercise group, n=24). They were assessed with neurological severi-ty scores (NSS), and the expression of Ki67 was determined with immunofluorescence, 3, 7, 14 and 21 days after training. Results Com-pared with the control group, the number of Ki67-labeled cells in subventricular significantly increased in the exercise group 14 and 21 days after ischemia (P<0.05), and the NSS decreased since 7 days after ischemia (P<0.05). Conclusion Wheel running may promote the neuro-genesis in subventricular of adult rats after cerebral infarction, which may associate with the recovery of neural function.关键词
脑梗死/运动训练/神经新生/大鼠Key words
cerebral infarction/exercise/neurogenesis/rats分类
医药卫生引用本文复制引用
方杰,胡昔权..运动训练对脑梗死大鼠室管膜下区神经新生的影响[J].中国康复理论与实践,2016,(1):8-12,5.基金项目
1.国家自然科学基金项目(No.81071607)；2.广东省科技计划项目(No.2011B060300013)。 （No.81071607）
