中国康复理论与实践Issue(2)：132-135,4.DOI:10.3969/j.issn.1006-9771.2016.02.002
跑台训练对大鼠脑缺血再灌注损伤后胶质纤维酸性蛋白和脑源性神经营养因子表达的影响
Effects of Treadmill Training on Expression of Glial Fibrillary Acidic Protein and Brain-derived Neurotrophic Factor in Rats with Cerebral Ischemia-reperfusion
谢宏文 1谢旭光2
作者信息
- 1. 聊城市人民医院康复医学科，山东聊城市252000
- 2. 聊城市疾病预防控制中心检验科，山东聊城市252000
- 折叠
摘要
Abstract
Objective To explore the effect of treadmill training on expression of glial fibrillary acidic protein (GFAP) and brain-derived neurotrophic factor (BDNF) after cerebral ischemia-reperfusion in rats. Methods 30 male Wistar rats were randomly divided into sham group, model group and treadmill training group, with 10 rats in each group. The latter 2 groups were modeled with middle cerebral artery occlusion for 2 hours and reperfusion. The treadmill training group underwent treadmill exercise on the 3rd day after modeling for 12 days. Neurological function was evaluated with modified Neurological Severity Scores (mNSS). The neuronal pathological change in ischemic cortex was observed with HE staining. The expressions of GFAP and BDNF in cortex were determined by Western blotting. Results Com-pared with the model group, the mNSS scores decreased in the treadmill training group (F=9.931, P<0.01), the pathological damage in the ischemia cortex significantly lessened, and the expressions of GFAP (t=6.73) and BDNF (t=3.78) increased (P<0.05). Conclusion Treadmill training may increase the expression of GFAP and BDNF after cerebral ischemia-reperfusion in rats, and promote the recovery of neurologi-cal function.关键词
跑台训练/缺血再灌注/胶质纤维酸性蛋白/脑源性神经营养因子/大鼠Key words
treadmill training/ischemia-reperfusion/glial fibrillary acidic protein/brain-derived neurotrophic factor/rats分类
医药卫生引用本文复制引用
谢宏文,谢旭光..跑台训练对大鼠脑缺血再灌注损伤后胶质纤维酸性蛋白和脑源性神经营养因子表达的影响[J].中国康复理论与实践,2016,(2):132-135,4.
