中国康复理论与实践Issue(2)：146-149,4.DOI:10.3969/j.issn.1006-9771.2016.02.005
热射病对大鼠空间学习记忆能力远期损害的研究
Long-term Impairment of Spatial Learning and Memory in Rats after Heat Stroke
摘要
Abstract
Objective To compare the spatial learning and memory function of heat stroke rats in different periods, to explore the long-term impairment. Methods 42 Sprague-Dawley rats were randomly divided into heat stroke 7 days group (HS7, n=21), heat stroke 21 days group (HS21, n=21), and another 18 rats were performed femoral artery intubation as surgery control group (sham, n=18). They were tested with Morris water maze 7 days and 21 days after modeling respectively for 5 days. The escaping latency, the frequency of crossing the platform area and the duration in the target quadrant were recorded. Results Compared with the sham group, the escaping latency prolonged in HS7 group in all the time (P<0.05), and 4th and 5th days in HS21 group (P<0.05). Compared with HS7 group, the escaping latency short-ened in HS21 group on the 3rd, 4th and 5th days (P<0.05). The duration in the target quadrant shortened in HS7 group compared with the sham group (P<0.05), and prolonged in HS21 group compared with HS7 group (P<0.05). The frequency of crossing the platform decreased both in HS7 group and HS21 group compared with the sham group (P<0.05), and no difference was found between the later 2 groups (P>0.05). Conclusion The impairment of spatial learning and memory is the most seriously 7 days after heat stroke in rats, and it may remain for long time.关键词
热射病/空间学习记忆/Morris水迷宫/远期损害/大鼠Key words
heat stroke/spatial learning and memory/Morris water maze/long-term impairment/rats分类
医药卫生引用本文复制引用
张云,万明胜,董会,吴士文..热射病对大鼠空间学习记忆能力远期损害的研究[J].中国康复理论与实践,2016,(2):146-149,4.基金项目
国家发改委卫星专项基金项目(No.发改办高技[2013]2140)。 （No.发改办高技[2013]2140）
