中国康复理论与实践Issue(2)：150-155,6.DOI:10.3969/j.issn.1006-9771.2016.02.006
小剂量超短波治疗对大鼠脊髓损伤后炎症反应及水肿的影响
Effects of Low Dose Ultrashort Wave Therapy on Inflammation and Edema after Spinal Cord Injury in Rats
摘要
Abstract
Objective To investigate the effect of ultrashort wave therapy on edema and inflammatory reaction after spinal cord injury (SCI) in rats. Methods 56 Sprague-Dawley rats were divided into sham-operated group (n=8), model group (n=24) and ultrashort wave group (n=24). The model was established with Allen's method. The sham-operated group was exposed endorhachis without hit. The ultra-short wave group was exposed to ultrashort wave radiation 7 minutes, once a day, 24 hours after modeling until the animals were sacrificed. Locomotors functional recovery was assessed every week post operation period by BBB score. Immunohistochemical staining was per-formed to observe the expression of the aquaporin-4(AQP-4) and ED-1. Results The BBB scores increased in the model group and the ultra-short wave group after treatment, and was higher in the ultrashort wave group than in the model group from 1 week after treatment (t>3.368, P<0.01). The expressions of AQP-4 and ED-1 were higher in the model group and ultrashort wave group than in the sham-operated group, and decreased as time went on. They were lower in the ultrashort wave group than in the model group(t>3.156, t>4.466, P<0.05). Conclu-sion Ultrashort wave therapy can alleviate the edema after SCI, reduce the activation and infiltration of inflammatory cells, and promote the recovery of neurological function.关键词
脊髓损伤/超短波/水通道蛋白-4/巨噬/小胶质细胞/大鼠Key words
spinal cord injury/ultrashort wave/aquaporin-4/macrophage/microglias/rats分类
医药卫生引用本文复制引用
万峪岑,孙师,赵利娜,尹艳梅,冯智萍,周禹鑫,张志强,张立新..小剂量超短波治疗对大鼠脊髓损伤后炎症反应及水肿的影响[J].中国康复理论与实践,2016,(2):150-155,6.基金项目
国家自然科学基金青年科学基金项目(No.81101462)。 （No.81101462）
