中国药理学与毒理学杂志Issue(2)：158-164,7.DOI:10.3867/j.issn.1000-3002.2016.02.011
鞘磷脂类信号通路在肺纤维化发病机制中的作用
Role of sphingolipids signaling in pathogenesis of pulmonary fibrosis
摘要
Abstract
Pulmonary fibrosis is a group of chronic lung diseases caused by various factors and characterized by chronic inflammations,lung tissue structure damage,increase of pulmonary interstitial collagen and massive deposition of extracellular matrix (ECM). Because of its complicated etiology, there is no effective treatment currently. Recent studies showed that the activation of sphingolipids signaling and pulmonary fibrosis were closely related. This paper describes the composition and function of sphingolipids signaling pathway and its effect on fibrosis in order to provide new ideas about further study of the pathogenesis of pulmonary fibrosis and methods of prevention.关键词
肺纤维化/鞘磷脂类/神经酰胺类/酸性神经酰胺酶Key words
pulmonary fibrosis/sphingolipids/ceramides/acid ceramidase分类
医药卫生引用本文复制引用
易吉平,曾明,何兴轩..鞘磷脂类信号通路在肺纤维化发病机制中的作用[J].中国药理学与毒理学杂志,2016,(2):158-164,7.基金项目
中南大学中央高校基本科研业务费专项资金资助（2015zzts284）@@@@The project supported by Fundamental Research Funds for the Central Universities of Central South University （）
