中国医学创新Issue(34)：1-4,4.DOI:10.3969/j.issn.1674-4985.2015.34.001
抗氧化治疗对2型糖尿病合并急性脑梗死患者RBP4及糖脂代谢的影响
Effect of Antioxidant Therapy on the Levels of Retinol Binding Protein 4 and Glucose-lipidmetabolism in Patients with Type 2 Diabetic Complicated with Acute Cerebral Infarction
摘要
Abstract
Objective:To research the efficacy of antioxidant therapy on the levels of retinol binding protein 4 and glucose-lipid metabolism in patients with type 2 diabetic complicated(T2DM) with acute cerebral infarction(ACI). Method:110 patients with T2DM complicated with acute cerebral infarction were randomized into two groups. Patients were treated with life style intervention,blood sugar, lipid, blood pressure, anti platelet aggregation and improved circulation drugs.On this basis , 56 cases of the treatment group were given alpha-lipoic acid 600 mg and 250 mL 0.9%sodium chloride solution,1 time/d,3 weeks;the control group was treated with vitamin C.The levels of RBP4,Cys-C, Hcy,hs-CRP,blood glucose(FPG、2 h PG、HbA1c), blood lipid,blood pressure and body weight were measured and the score of NIHSS was evaluated before and after the treatment.Result:After one course of treatment,the levels of RBP4,Cys-C,Hcy,hs-CRP,FPG,2 h PG,HbA1c,TG,TC,HOMA-IR were decreased of two groups, the treatment group was better than the control group,the differences were statistically significant(P<0.01). After treatment, the NIHSS score of the two groups were decreased, and the treatment group was significantly lower than that of the control group,the difference was statistically significant(P<0.01); the two groups were not found significant adverse reaction.Conclusion:The treatment of type 2 diabetes with acute cerebral infarction, which can significantly reduce RBP4 and blood glucose, blood lipid level, improve the function of islet beta cells and can reduce the NIHSS score.关键词
α-硫辛酸/2型糖尿病/脑梗死/血清视黄醇结合蛋白4Key words
Alpha-lipoic acid/Type 2 diabetes mellitus/Cerebral infarction/Retinol binding protein 4引用本文复制引用
赵亮,赵健康..抗氧化治疗对2型糖尿病合并急性脑梗死患者RBP4及糖脂代谢的影响[J].中国医学创新,2015,(34):1-4,4.基金项目
国家高技术研究发展计划（863计划）子课题（2014AA022304）；临沂市科技项目 （）
