摘要
Abstract
ObjectiveTo investigate the clinical effect of acyclovir combined with narrow-band UVB (NB-UVB) phototherapy in the treatment of herpes zoster, analyse the prevention of postherpetic neuralgia value. Method137 patients with herpes zoster were divided into control group (n=67) and treatment group (n=70) according to the random number table method. Two groups were treated with conventional symptomatic treatment, control group patients were treated with acyclovir, treatment group patients were treated with NB-UVB on the basis of treatment group. Two groups of treatment for 2 weeks. Compared two groups of patients with clinical curative effects, recovery time of symptoms and signs, visual analogue scale (VAS), the changes of serum cytokine levels and adverse reactions occur and follow-up of postherpetic neuralgia occurrence.ResultThe total effective rate in treatment group was higher than control group (P<0.05). The cessation time, scab, decrustation, pain relief time in treatment group were shorter than control group (P<0.05). There was no significant difference in VAS scores between the two groups before treatment (P>0.05); after treatment, the VAS scores of two groups were signiifcantly lower than before treatment (P<0.05), and treatment group was lower than control group (P<0.05). After treatment, the levels of serum IL-6 and CRP in treatment group were lower than control group (P<0.05). There were no obvious adverse reactions in the two groups during the treatment period. After 6 months of follow-up, treatment group patients with postherpetic neuralgia incidence was signiifcantly lower than control group (P<0.05).Conclusion Acyclovir combined with NB-UVB in the treatment of herpes zoster has curative effect, and can signiifcantly prevent postherpetic neuralgia.关键词
阿昔洛韦/窄谱中波紫外线/带状疱疹/疗效/后遗神经痛Key words
Acyclovir/Narrow-band UVB/Herpes zoster/Efifcacy/Postherpetic neuralgia
