摘要
Abstract
Alzheimer's disease (AD) is the most common cause of dementia, neurodegenera-tive diseases, mainly characterized by progressive cognitive dysfunction and behavioral disabilities, its pathological characteristics are nerve cells outside insoluble amyloid beta and intracellular fiber which is formed by a phosphorylated tau tangles. This kind of extracellular oligomeric is mainly composed of Aβ, which is sequentially cleavaged the amyloid precursor protein APP byβ-secretase andγ-secretase. Deposition and excessive tau protein phosphorylation in cells form a nerve fiber tangles (NFTs), so as to cause oxidative stress and chronic inflammation damage, which leads to neuronal loss and synaptic dysfunction. In the past, based on the understanding of AD pathology characteristics, we focused on Aβand NFTs as the main direction of AD treatment, but over decades of research we have not made great progress. In recent years, as the in-depth and developmental understanding of beta amyloid protein precursor protein (APP) processing, people pay more and more attention toβ-site APP-Cleav-ing Enzyme 1, a key enzyme in Alzheimer disease (AD). Therefore, theβ-secretase (BACE1) related features ,functions and the related treatment progress in Alzheimer disease are reviewed in this paper.关键词
人β-分泌酶/阿尔茨海默病/β淀粉蛋白前体蛋白Key words
BACE1 protein, human/Alzheimer Disease/Amyloid beta-protein precursor
