转化医学杂志Issue(1)：19-23,5.DOI:10.3969/j.issn.2095-3097.2016.01.005
Toll样受体9基因多态性与重症肌无力相关性研究
Correlation between Toll-like receptor 9 gene polymorphism and myasthenia gravis
摘要
Abstract
Objective To investigate the correlation between Toll-like receptor 9 ( TLR9 ) polymorphism and the susceptibility, severity and short-term effect of glucocorticoid in myasthenia gravis ( MG) patients. Methods One hundred and nine MG patients and 162 healthy controls in Han Chinese population were enrolled. Subgroups were divided by gender, onset age, thymoma sta-tus, Osserman type, Oosterhuis score and short-term effect of glucocorticoid. Rs352140 and rs187084 were genotyped by polymerase chain reaction-based restriction fragment length polymor-phism (PCR-RFLP) method. Allele frequencies and genotype frequencies (under codominant, log-additive and over-dominant mode of inheritance) were compared between MG/control group, MG subgroups/control group and each pairs of MG subgroups. Results In rs352140 and rs187084, there were no significant differences in allele frequencies and genotype frequencies ( under codomi-nant, log-additive and over-dominant mode of inheritance ) among MG/control group, MG sub-groups/control group and MG subgroups ( P>0. 05 ) . Conclusion No correlation was found be-tween rs352140 and rs187084 polymorphisms and the susceptibility, severity and short-term effect of glucocorticoid in myasthenia gravis patients.关键词
重症肌无力/Toll样受体9/基因多态性Key words
Myasthenia gravis/Toll like receptor 9(TLR9)/Gene polymorphism分类
医药卫生引用本文复制引用
岳耀先,洪宇,王淑霞,王琦,张贤军,高翔,张栩,李海峰..Toll样受体9基因多态性与重症肌无力相关性研究[J].转化医学杂志,2016,(1):19-23,5.基金项目
国家自然科学基金(81070963)；山东省自然科学基金资助( ZR2010HM019) （81070963）
