中山大学学报（自然科学版）Issue(1)：12-15,4.
田基黄总黄酮抗胆管结扎所致大鼠肝纤维化的研究
Therapeutic effects of total flavonoids of Hypericum japonicum against liver fibrosis induced by bile duct ligation in rats
摘要
Abstract
The purpose of this study was to investigate the therapeutic effects of total flavonoids of Hyperi-cum japonicum against liver fibrosis induced by bile duct ligation in rats.Liver fibrosis model was estab-lished by bile duct ligation.After bile duct ligation,the treatment groups orally received total flavonoids of Hypericum japonicum (9,18,36 mg·kg -1 ·d -1 )daily for 4 weeks.Then,rats were all executed. Serum and liver tissues were obtained.Serum levels of TBIL,DBIL,ALT,AST,HA,LN,PCⅢ,TNF-αand the activities of SOD,GSH-Px and the contents of MDA,Hyp,MMP -1 and TIMP -1 in liver tis-sues were detected.Results showed that total flavonoids of Hypericum japonicum could significantly allevi-ate liver fibrosis,as indicated by decreasing levels of TBIL,DBIL,ALT,AST,HA,LN,PCⅢ,TNF -α,Hyp and TIMP -1.Moreover,total flavonoids of Hypericum japonicum could effectively enhance the activities of SOD,GSH-Px and decrease the content of MDA.Our results show that total flavonoids of Hy-pericum japonicum is effective in attenuating liver fibrosis induced by bile duct ligation in rats,at least partly,via enhancing the activation of antioxidant enzymes and inhibiting release of TNF-α.关键词
田基黄总黄酮/肝纤维化/胆总管结扎Key words
total flavonoids of Hypericum japonicum/liver fibrosis/bile duct ligation分类
医药卫生引用本文复制引用
王永刚,谭沛,李沛波,徐冰,苏薇薇,陈周全,彭维..田基黄总黄酮抗胆管结扎所致大鼠肝纤维化的研究[J].中山大学学报（自然科学版）,2016,(1):12-15,4.基金项目
广东省科技计划重大专项资助项目（2012A080202011）；广州开发区科技领军人才资助项目 （）
