滨州医学院学报2016，Vol.39Issue(1)：1-4,4.
肺复康合剂联合地塞米松对大鼠肺纤维化的抑制作用❋
The inhibition role of Feifukang mistura combined with dexamethasone on rat pulmonic fibrosis
摘要
Abstract
Objective To study the inhibition role of Feifukang mistura combined with dexamethasone on rat pulmonic fibro-sis.Methods The 40 male SD rats were randomized into the control group,model group (blemycin model,BLM),dexametha-sone group (dexamethasone,DEX),Feifukang group (Feifukang mistura),and Feifukang + DEX group (Feifukang mistura+DEX).Except for the control group,the rest groups were established the animal model of pulmonary fibrosis.After 28-day post-drug administration,the changes of weight and lung coefficient,serum hyaluronic acid (HA),laminin (LN),type IV collagen (CIV)in the all groups were observed and compared.Results compared with the control group,the weight was significantly re-duced,the lung coefficient,HA,LN,CIV levels were obviously increased in the model group,P <0.05;compared with the model group,the weight was significantly increased,the lung coefficient,HA,LN,CIV levels were obviously decreased in the DEX group,Feifukang group and Feifukang + DEX group,P <0.05;compared with the DEX group,the all paremeters changes in the Feifukang + DEX group were more significant,P <0.05.Conclusion The treatment of Feifukang mistura combined with dexamethasone can inhibit the rat pulmonic fibrosis by inhibition of fibrosis cell proliferation.关键词
肺复康合剂/地塞米松/肺纤维化/增殖Key words
feifukang mistura/DEX/pulmonic fibrosis/proliferation分类
医药卫生引用本文复制引用
赵敏,李炯,宋晓冬,吕长俊..肺复康合剂联合地塞米松对大鼠肺纤维化的抑制作用❋[J].滨州医学院学报,2016,39(1):1-4,4.基金项目
?基金项目:国家自然科学基金(81273957) （81273957）
滨州医学院科技重点计划(BY2012KJZD10) （BY2012KJZD10）
