川北医学院学报2016，Vol.31Issue(1)：55-57,69,4.DOI:10.3969/j.issn.1005-3697.2016.01.15
二甲双胍缓释片治疗非典型抗精神病药致精神分裂症糖脂代谢紊乱的临床研究
A clinical study of metformin sustained release tablets in the treatment of schizophrenia and glucose and lipid metabolism disorder induced by atypi-cal antipsychotic agents
摘要
Abstract
Objective:To investigate the clinical effect of metformin sustained release tablets on the disorder of schizophrenia and glucose metabolism in schizophrenia caused by atypical antipsychotics.Methods:104 patients with schizophrenia were randomly di-vided into treatment group and control group,52 cases in each group.All patients were treated with atypical antipsychotic agents,and the patients in treatment group were combined with metformin hydrochloride sustained release tablets.Before and after treatment reflec-ting glycemic index including bBody mass index (BMI),fasting blood glucose metabolism blood glucose (FBG)and postprandial 2 h blood glucose (2 h PBG)]and blood fat index [total cholesterol,total cholesterol (TC),triglyceride (TG),low density lipoprotein particles lipoprotein (LDL)],and high-density lipoprotein (high density lipoprotein,HDL)were monitored to record the occurrence of adverse reactions.Results:The magnitude of the decrease of BMI,FBG and 2hpbg after treatment in the treatment group were larger than those in control group (P <0.05).The levels of TC,TG and LDL were reduced after treatment in the treatment group,the increase in HDL levels higher than that of control group (P <0.05 );adverse reaction in the treatment group occurred rate (15.38%)only slightly higher than that of the control group (9.62%)(P >0.05 ).Conclusion:The metformin sustained release tablets have good clinical efficacy,safety and safety for the treatment of schizophrenia and schizophrenia with schizophrenia and schizophrenia.关键词
非典型抗精神病药/二甲双胍/糖代谢/脂代谢Key words
Atypical antipsychotic drugs/Metformin/Glucose metabolism/Lipid metabolism分类
医药卫生引用本文复制引用
周进涛,崔中芹,刘燕朋,连俊红,裴介子..二甲双胍缓释片治疗非典型抗精神病药致精神分裂症糖脂代谢紊乱的临床研究[J].川北医学院学报,2016,31(1):55-57,69,4.基金项目
洛阳市科技支撑计划课题 （）
