国际妇产科学杂志2016，Vol.43Issue(1)：8-10,3.
基质金属蛋白酶降解胞外基质致未足月胎膜早破研究进展
Research Progress of Matrix Metalloproteinases in Preterm Premature Rupture of Membranes through Degrading Extracellular Matrix
李雯 1常颖 1李星 2徐亚玲2
作者信息
- 1. 300100 天津市中心妇产科医院
- 2. 天津医科大学
- 折叠
摘要
Abstract
Preterm birth is the first critical factor of life, threatening diseases for the perinatal. According to the statistics, the preterm birth rate in China reached 8.1%in 2012. And the frequency of preterm premature rupture of membranes (PPROM) is about 25%-30%, and intrauterine infection is the principal element. The recent research shows that a molecular mechanism of PPROM is advanced degradation of extracellular matrix, which due to the activation of matrix metalloproteinases (MMPs) in fetal membrane. The high expression of cytokines, such as IL-1, IL-6 and TNF-α, maybe the reason of MMPs′activation. The process of activation and secretion of MMPs in term labor and preterm birth still need to be explored, which may be considered as a marker of pregnancy outcome. MMPs can provide a breakpoint of prevention and therapy for PPROM.关键词
基质金属蛋白酶类/感染/细胞因子类/早产/胎膜早破Key words
Matrix metalloproteinases/Infection/Cytokines/Premature birth/Fetal membranes/premature rupture引用本文复制引用
李雯,常颖,李星,徐亚玲..基质金属蛋白酶降解胞外基质致未足月胎膜早破研究进展[J].国际妇产科学杂志,2016,43(1):8-10,3.
