摘要
Abstract
Objective To investigate the changes of procalcitonin (PCT) level in neonatal sepsis and its value in the prognosis of patient neonates .Methods From September 2012 to December 2014 98 cases of neonatal sepsis admitted in pediatric department of Maternal and Child Health Hospital of Zhejiang City were selected in study group , and 40 healthy neonates selected at the same period were in control group.Two groups were compared in PCT , C reactive protein, white blood cell (WBC), and acute physiology and chronic health score (APACHE II), and neonatal critical illness score (NCIS) was used to group neonates with sepsis .Receiver operating characteristic curve ( ROC) was used to analyze the clinical value of PCT on judging the prognosis of sepsis in neonates .Results In study group PCT , CRP and WBC were 15.37 ±7.16ng/L, 39.82 ±11.75mg/L and (15.8 ±3.17) ×109/L, respectively, and they were significantly higher than those in the control group [0.84 ±0.72ng/L, 1.96 ±1.35mg/L, (9.4 ±2.1) ×109/L] (t value was 12.78, 20.28 and 11.75, respectively, all P<0.05).There were 36 cases of non-critically ill neonates, 33 critical ill neonates and 29 extreme ill neonates.Group comparison showed that PCT , CRP, WBC and APACHEⅡwere lowest in non-critically ill group , followed by critical ill group and extreme critically ill group (F value was 14.09, 14.18, 10.05 and 7.88, respectively, all P<0.05), and the differences revealed in group comparison were statistically remarkable (P<0.05).In the group with PCT≥14.86μg/L, 21 of 43 cases died with mortality of 48.84%, which was remarkably higher than 14.55%in the group with PCT <14.86μg/L (χ2 =13.62,P<0.05).ROC revealed that AUC of PCT predicting poor prognosis was 0.862, which was higher than 0.800.Conclusion PCT level is significantly higher in neonates with sepsis than in normal neonates , and it has certain relationship with the severity of disease in neonates .It has certain value as a clinical index to predict the prognosis of neonates with sepsis .关键词
降钙素原/脓毒血症/新生儿/预后Key words
procalcitonin(PCT)/sepsis/newborn/prognosis分类
医药卫生
