摘要
Abstract
Objective To explore pregnancy outcomes and alteration of renal function of pregnant women with nephrotic syndrome ( NS) . Methods From January 2008 to December 2014, clinical data of 54 pregnant women with NS ( observation group ) and another 54 randomly selected cases with normal pregnancy ( control group ) in Ningbo First Hospital were retrospectively analyzed and compared , and risk factors influencing neonatal outcomes were also analyzed .Results Serum total protein and the weeks of gestational in the observation group were significantly lower than the control group (t value was 4.09 and 3.30, respectively, both P<0.05), but systolic pressure, diastolic pressure , serum creatinine , urea nitrogen , cholesterol , urine protein and uric acid in the observation group were significantly higher than in the control group (t value was 2.72, 2.93, 4.14, 4.09, 2.47, 10.17 and 5.44, respectively, all P<0.05).The incidence of neonatal asphyxia was significantly higher in the observation group than in the control group (χ2 =4.43,P<0.05).The incidence of postpartum hemorrhage was higher in the observation group , but the difference was not significant (χ2 =3.20,P>0.05).Logistic regression analysis showed that the risk coefficient of hypertension (OR=4.36,P<0.05) was highest, followed by high serum creatinine (OR=3.54, P<0.05).Conclusion More complications and risk occur in pregnancy complicated with NS .Hypertension and high serum creatinine are the primary risk factors of fetus .关键词
妊娠/肾病综合征/肌苷/新生儿窒息发生率Key words
pregnancy/nephrotic syndrome(NS)/creatinine/incidence of neonatal asphyxia分类
医药卫生
