摘要
Abstract
Objective To discuss the clinical effect of preoperative neoadjuvant chemotherapy (NACT) combined with radical hysterectomy treatment on Ⅰb2-Ⅱb cervical cancer .Methods A retrospective analysis was conducted on clinical data of 89 cases of cervical cancer treated in Yu’nan County Second People ’s Hospital from July 2009 to September 2011.The cases were divided into chemotherapy group (preoperative chemotherapy and surgery , 47 cases) and surgery group (direct use of surgery, 42 cases), and two groups were compared in short-term efficacy, 3-year disease-free survival rate and 3-year overall survival rate .Results The overall effective rate of chemotherapy group was 92.86%, 80.00%and 69.23%, respectively at stage Ⅰb2,Ⅱa andⅡb, and the difference was not significant (χ2 =2.447, P=0.294).The total effective rate of squamous cell carcinoma was 95.83%, which was obviously higher than adenocarcinoma (χ2 =5.738,P=0.017).The differences in operative time and intraoperative blood loss were not significant between chemotherapy group and surgery group (both P>0.05).Of specimens in chemotherapy group and surgery group , vaginal positive margin rate was 4.26% and 2.38%, respectively, and the difference was not remarkable (P >0.05).Lymph node metastasis rate and vascular invasion rate in chemotherapy group was 12.77 % and 17.02%, respectively, which were significantly lower than those in surgery group (χ2 value was 4.369 and 8.957, respectively, both P<0.05).In chemotherapy group 3-year disease-free survival rate was 78.72% (37/47), which was significantly higher than that of surgery group (50.00%, 21/42) (χ2 =8.062, P=0.005), but 3-year survival rate of the former (88.23%, 41/47) was not significantly higher than the later (80.95%,34/42) (χ2 =0.660, P=0.416).Conclusion For patients with cervical cancer at Ⅰb2-Ⅱb, NACT before surgery can significantly improve the resection rate , reduce lymph node metastasis and vascular invasion, and prolong postoperative survival time .关键词
宫颈癌/新辅助化疗/宫颈癌根治术/临床效果Key words
cervical cancer/neoadjuvant chemotherapy(NACT)/radical hysterectomy/clinical effect分类
医药卫生
