海南医学院学报2016，Vol.22Issue(9)：892-894,3.DOI:10.13210/j.cnki.jhmu.20160125.040
无创正压通气在 COPD 急性加重期呼吸衰竭治疗中的作用
Efficacy of non-invasive positive pressure ventilation in treatment of respiratory failure in pa-tients with COPD at acute exacerbation stage
摘要
Abstract
Objective:To observe the efficacy of non-invasive positive pressure ventilation (NIPPV)in the treatment of respiratory failure in patients with COPD at the acute exacerbation stage.Methods:A total of 38 COPD patients at the acute ex-acerbation stage with respiratory failure who were admitted in our hospital from January,2012 to January,2013 with complete medical materials were included in the study and divided into the observation group and the control group according to different treatment methods.On admission,the patients in the two groups were given oxygen inhalation,positive infection control,and drugs that could improve the respiratory function.On the basis,the patients in the observation group were given additional NIPPV.The improvement of blood gas indicators 4,24,72 d after admission,and 5,30 d after discharge in the two groups was compared.The hospitalization time and the number of second hospitalization within 3 months in the two groups were com-pared.Results:In the observation group,pH value after 4 h ventilation was significantly elevated (P <0.05),and maintained at a stable state after 24 h ventilation,while in the control group,the change of pH value was not statistically significant (P >0.05),and after 5 d treatment,pH value was yet low.In the observation group,PaCO 2 was significantly reduced in a short ventilation time (P <0.05),while in the control group,the descending range was small.The differneces of pH and PaCO 2 4 h, 24 h,72 h,and 5 d after treatment between the two groups was statistically significant (P < 0.05 ),but PaCO 2 in the two groups could not reduce to the normal level.PaO 2 after treatment in the two groups was improved,but the improved degree in the observation degree was significantly superior to that in the control group (P <0.05).Thedifference of blood gas indicators 30 d after discharge between the two groups was not statistically significant (P >0.05).The hospitalization time in the observa-tion group was shortened,and the number of second hospitalization within 3 months was significantly lower than that in the control group (P <0.05).Conclusions:NIPPV can rapidly correct the respiratory failure state in patients with COPD merged with respiratory failure,improve the pulmonary function,and reduce the lung injury,with an accurate efficacy.关键词
慢性阻塞性肺疾病/呼吸衰竭/无创正压通气Key words
NIPPV/COPD/Respiratory failure分类
医药卫生引用本文复制引用
李德鹏..无创正压通气在 COPD 急性加重期呼吸衰竭治疗中的作用[J].海南医学院学报,2016,22(9):892-894,3.基金项目
河北钢铁集团科学技术获奖项目(2014008102)[Foundation Project]:The study was supported by the Scientific and Technological Awards Project of Iron and Steel Group in Hebei Province with the number of 2014008102． （2014008102）
