海南医学院学报2016，Vol.22Issue(9)：906-909,4.DOI:10.13210/j.cnki.jhmu.20160125.043
小儿热性惊厥用左乙拉西坦治疗后的复发情况及血清学指标变化研究
Recurrence and serum indicator change after levetiracetam treatment of children febrile con-vulsion
摘要
Abstract
Objective:To analyze the recurrence and serum indicator change after levetiracetam treatment of children fe-brile convulsion.Methods:A total of 92 children with febrile convulsion who received treatment in our hospital from March 2012 to December 2014 were selected as research subjects and randomly divided into observation group and control group ac-cording to different treatment methods,each group with 46 cases.Control group received conventional therapy,observation group received levetiracetam combined with conventional therapy,and then differences in recurrence of febrile convulsion,cra-nial nerve-related factors,contents of trace elements and iron as well as humoral and cellular immune function of two groups were compared.Results:Average number of fever,frequency of recurrence of convulsion and the proportion of developing to epilepsy of observation group after treatment were less than those of control group,and the time from the end of treatment to the first convulsive seizure was longer than that of control group (P <0.05);serum NSE,S-100βand BDNF levels of observa-tion group after treatment were lower than those of control group (P <0.05);serum Ca2 + ,P,SI and SF levels of observation group after treatment were higher than those of control group,and ALP level was lower than that of control group (P <0.05);serum IgA,IgM,IgG and CD8 + levels of observation group after treatment were lower than those of control group,and levels of CD4 + and CD4 +/CD8 + were higher than those of control group (P <0.05).Conclusion:Levetiracetam therapy for children with febrile convulsion reduces convulsive seizure and meantime can optimize children’s microenvironment and enhance immune function.关键词
热性惊厥/左乙拉西坦/复发/血清学指标/儿童Key words
Febrile convulsion/Levetiracetam/Recurrence/Serum indicators分类
医药卫生引用本文复制引用
孟慧琴..小儿热性惊厥用左乙拉西坦治疗后的复发情况及血清学指标变化研究[J].海南医学院学报,2016,22(9):906-909,4.基金项目
河南焦作卫生局临床研究项目(2015KY023)[Foundation Project]:It is supported by Clinical Research Project of Health Bureau of Jiaozuo (2015KY023)． （2015KY023）
