海南医学院学报2016，Vol.22Issue(9)：916-920,5.DOI:10.13210/j.cnki.jhmu.20160125.001
老年早中期膝骨关节炎患者补肾舒筋方内服、熏洗联合玻璃酸钠腔内注射后的病情评估
Effect of kidney-tonifying and tendons-relaxing formula orally combined with fumigations and odium hyaluronate injection on elderly patients with knee osteoarthritis at early and middle stage
摘要
Abstract
Objective:To analyze the effect of kidney-tonifying and tendons-relaxing formula orally combined with fumi-gations and odium hyaluronate injection on elderly patients with knee osteoarthritis at early and middle stage.Methods:A total of 78 cases of elderly knee osteoarthritis were selected in our hospital from August 201 1 to February 2014 as observation group. A total of 88 joint function normal healthy people were chosen as the control group.After treatment,differences of serum pro-tein expressions and CTX II,COMP,HA levels as well as related factors of Hippo-Yap signaling pathway in the synovial flu-id,such as HMGB2,CCL1 and PD-1of the two groups were compared.Results:After treatment,serum PON-1,paraoxonase-3,AMBP,ApoM,KAP and TN expression levels in the observation group were higher than those of the control group pa-tients.APOL1 level was lower than that of the control group (P <0.05).After 1 month,3 months and 6 months’treatment, serum COMP level in the observation group was lower than that in the control group patients.CTX II,HA levels were higher than those in the control group (P <0.05).After 1 month,3 months and 6 months’treatment YAP,BCL-2 levels in synovial fluid in the observation group were higher than those in the control group (P <0.05).Synovial fluid HMGB2 CCL1,NO and PD-1 levels of the observation group patients after treatment were lower than those of the control group (P <0.05 ).Conclu-sions:The elderly patients with early and middle stage knee osteoarthritis can be treated by oral administration,fumigation combined with sodium hyaluronate injection in the treatment of knee osteoarthritis,which can optimize the whole body and lo-cal non-infective inflammatory state,and promote the rehabilitation of the patients.关键词
膝骨关节炎/补肾舒筋方/玻璃酸钠腔/老年人Key words
Knee osteoarthritis/Kidney-tonifying and tendons-relaxing formula/Sodium hyaluronate/Elder分类
医药卫生引用本文复制引用
黄红光,袁光华,陈康,郑啸..老年早中期膝骨关节炎患者补肾舒筋方内服、熏洗联合玻璃酸钠腔内注射后的病情评估[J].海南医学院学报,2016,22(9):916-920,5.基金项目
湖北省教育厅科研项目(B20112112)[Foundation Project]:It is supported by Science Research Project of Education Project of Hubei Province (B20112112)． （B20112112）
