海南医学院学报2016，Vol.22Issue(9)：924-927,4.DOI:10.13210/j.cnki.jhmu.20160106.014
PIK3CD 表达量检测对胃癌临床病理分期及恶性程度的评估价值
Assessment value of PIK3CD expression detection on cl inicopathological staging and mal ig-nant degree of gastric cancer
摘要
Abstract
Objective:To analyze the assessment value of PIK3CD expression detection in clinicopathological staging and malignant degree of gastric cancer.Methods:A total of 92 cases of each of tumor tissue,precancerous tissue and blood samples from patients who received radical operation of gastric cancer in our hospital from January 2012 to July 2014 were collected. PIK3CD expression levels in tumor tissue as well as values of indicators of malignancy osteopontin (OPN),CD44v6,E-cadher-ine (E-CD),osteoblast-specific factor-2 (OSF-2),pepsinogen Ⅰ(PGⅠ),carbohydrate antigen 72-4 (CA72-4),monoclonal gastric cancer 7 antigen (MG7Ag),micro RNA-21 (miR-21)and let-7a in serum were detected,and the correlation between PIK3CD expression level and values of indicators of malignancy was further analyzed.Results:PIK3CD expression levels in tumor tissue and paracancer tissue of Ⅳ stage patients were higher than those in corresponding parts of Ⅰ stage,Ⅱ stage and Ⅲ stage patients (P <0.05);serum OPN,CD44v6,E-CD and OSF-2 levels of Ⅳ stage gastric cancer patients were higher than those of Ⅰ stage,Ⅱ stage and Ⅲ stage patients (P <0.05);serum PGⅠ and let-7a levels of Ⅳ stage gastric cancer pa-tients were lower than those of Ⅰ stage,Ⅱ stage and Ⅲ stage patients,while CA72-4,MG7Ag and miR-21 levels were higher than those of Ⅰ stage,Ⅱ stage and Ⅲ stage patients (P <0.05);PIK3CD expression level was directly proportional to OPN, CD44v6,E-CD,OSF-2,CA72-4,MG7Ag and miR-21 levels and inversely proportional to PGⅠ and let-7a levels (P <0.05). Conclusion:PIK3CD is highly expressed in gastric cancer tissue,PIK3CD expression has direct correlation with a number of in-dicators of malignancy,and it can be used as a sensitive index for assessing the condition of gastric cancer.关键词
胃癌/临床病理分期/PIK3CD/恶性程度Key words
Gastric cancer/Clinicopathological staging/PIK3CD/Malignancy分类
医药卫生引用本文复制引用
王雷,蔡冰..PIK3CD 表达量检测对胃癌临床病理分期及恶性程度的评估价值[J].海南医学院学报,2016,22(9):924-927,4.基金项目
陕西省科技计划项目(SJ08H213)[Foundation Project]:This study was supported by Science and Technology Program of Shaanxi Province (grant No ．SJ 08H213)． （SJ08H213）
