海南医学院学报2016，Vol.22Issue(10)：961-963,967,4.DOI:10.13210/j.cnki.jhmu.20160113.003
瑞舒伐他汀治疗对慢性心力衰竭患者心功能、炎性因子及基质金属蛋白酶的影响
Influence of cardiac function,inflammatory factor and matrix metalloproteinases in chronic heart failure patients with the treatment of rosuvastatin
摘要
Abstract
Objective:To explore the influence of cardiac function,inflammatory factor and matrix metalloproteinases (MMP)in chronic heart failure (CHD)patients with the treatment of rosuvastatin.Methods:A total of 100 cases of CHF were chosen as the research object and divided into observation group and control group according to random number table method, 50 cases in each group.Patients in two groups were given routine CHF treatment,and on this basis,patients in the observation group were given rosuvastatin,treated for 6 months,compared the cardiac function indexes:left ventricular ejection fraction (LVEF),left ventricular end-diastolic diameter (LVEDD)and left ventricular end systolic diameter (LVESD),inflammatory factor:high sensitivity C-reactive protein (hs-CRP)and interleukin 6 (IL-6)and tumor necrosis factorα(TNF-α)and MMPS:MMP-2 and MMP-9 in two groups before and after treatment.Results:The levels of LVEF in observation group after treat-ment were significantly higher than before and the control group after treatment,and the levels of LVEDD,LVESD,hs-CRP, IL-6,TNF-α,MMP-2 and MMP-9 were significantly lower than before and the control group after treatment (P <0.05);the levels of LVEF in control group after treatment were significantly higher while the levels of LVEDD,LVESD,MMP-2 and MMP-9 were significantly lower than before the treatment (P <0.05).Conclusion:Rosuvastatin can significantly improve car-diac function in patients with CHF and may be related to its inhibitory effect of inflammation and ventricular remodeling.关键词
瑞舒伐他汀/慢性心力衰竭/心功能/炎性因子/基质金属蛋白酶Key words
Rosuvastatin/Chronic heart failure/Cardiac function/Inflammatory factor/Matrix metalloproteinases分类
医药卫生引用本文复制引用
徐洁,骆小梅,胡强..瑞舒伐他汀治疗对慢性心力衰竭患者心功能、炎性因子及基质金属蛋白酶的影响[J].海南医学院学报,2016,22(10):961-963,967,4.基金项目
新疆维吾尔族自治区省级攻关项目(2013544B159)[Foundation Project]This study was supported by Provincial key project of Xinjiang Uygur Autonomous Region (NO．2013544B159)． （2013544B159）
