海南医学院学报2016，Vol.22Issue(10)：972-975,4.DOI:10.13210/j.cnki.jhmu.20160106.004
二甲双胍联用六味地黄丸对 T2DM 并 NAFLD 患者血清病情相关分子含量的影响
Effect of metformin combined with Liuwei Dihuang pill on serum illness-related molecule con-tents in T2DM patients with NAFLD
摘要
Abstract
Objective:To study the effect of metformin combined with Liuwei Dihuang pill on serum illness-related mol-ecule contents in type 2 diabetes mellitus (T2DM)patients with non-alcoholic fatty liver disease (NAFLD).Methods:A total of 86 cases of newly diagnosed T2DM patients with NAFLD were selected for study and randomly divided into combination therapy group and monotherapy group who received metformin combined with Liuwei Dihuang pill therapy and metformin monotherapy respectively,and then serum glycolipid metabolism indexes,liver function indexes as well as oxidative stress re-sponse and inflammatory response indexes of two groups were detected.Results:(1 )Glycolipid metabolism indexes:fasting plasma glucose (FPG),2-h plasma glucose (2hPG),haemoglobin A1c (HbA1c),mean amplitude of glycemic excursion (MAGE),HOMA-IR,triglyceride (TG),total cholesterol (TC)and low-density lipoprotein cholesterol (LDL-C)as well as body mass index (BMI)and waist hip ratio of combination therapy group were lower than those of monotherapy group (P <0.05),and high-density lipoprotein cholesterol (HDL-C)content was significantly higher than that of monotherapy group (P <0.05);(2)liver function indexes:aspartate transaminase (AST),alanine aminotransferase (ALT),γ-glutamyl transpeptidase (γ-GT),serum total bilirubin (STB)and cholyglycine (CG)contents of combination therapy group were significantly lower than those of monotherapy group (P <0.05);(3)oxidative stress response and inflammatory response indexes:malondialde-hyde (MDA),advanced oxidation protein products (AOPP),tumor necrosis factor-α(TNF-α)and interleukin (IL)-6 contents of combination therapy group were significantly lower than those of monotherapy group (P < 0.05 ).Conclusion:Metformin combined with Liuwei Dihuang pill helps to regulate glycolipid metabolism,reduce liver function damage and alleviate oxidative stress response and inflammatory response in T2DM patients with NAFLD.关键词
非酒精性脂肪性肝病/2 型糖尿病/肝功能/氧化应激反应/炎症反应Key words
Nonalcoholic fatty liver disease/Type 2 diabetes mellitus/Liver function/Oxidative stress response/In-flammatory response分类
医药卫生引用本文复制引用
郑仲萍,田峰,郑志刚,张国庆,郭锋,郭杏花..二甲双胍联用六味地黄丸对 T2DM 并 NAFLD 患者血清病情相关分子含量的影响[J].海南医学院学报,2016,22(10):972-975,4.基金项目
深圳市盐田区经济促进局项目(2013-1-1-6)[Foundation Project]:This study was supported by Project of Bureau of Economic Promotion of Yantian District ,Shenzhen City (No ．2013-1-1-6)． （2013-1-1-6）
