海南医学院学报2016，Vol.22Issue(10)：992-995,4.DOI:10.13210/j.cnki.jhmu.20160113.004
周围型肺癌患者接受微波消融联合放化疗后的肿瘤恶性程度评估
Tumor grade evaluation after patients with peripheral lung cancer received microwave abla-tion combined with radiochemotherapy
摘要
Abstract
Objective:To study the effect of microwave ablation combined with radiochemotherapy on tumor grade of patients with peripheral lung cancer.Methods:A total of 84 cases of patients diagnosed with Ⅲ stage peripheral non-small cell lung cancer in our hospital from May 2010 to October 2014 were selected for study and randomly divided into two groups,com-bination group which received microwave ablation combined with radiochemotherapy,control group which received radiochemo-therapy,and then serum tumor marker contents as well as mRNA contents of pro-apoptotic molecules,anti-apoptotic mole-cules,protease molecules,epithelial to mesenchymal transition (EMT)marker molecules and autophagy marker molecules in tumor tissue were detected.Results:A total of 2 weeks,4 weeks,6 weeks,8 weeks,10 weeks and 12 weeks after chemother-apy,serum carcinoembryonic antigen (CEA)and CYFRA21-1 contents of combination group were significantly lower than those of control group;12 weeks after chemotherapy,mRNA contents of Caspase-8,Fas,FasL,E-cadherin,cytokeratin, pULK,Benlin-1,PI3KC3,Atg-1,Atg-13,Atg-1 7,Atg-21 and Atg-24 in tumor tissue of combination group were significant-ly higher than those of control group (P <0.05);mRNA contents of c-myc,Survivin,matrix metalloproteinase (MMP)-2, MMP-9,MMP-13,N-cadherin and vimentin were significantly lower than those of control group (P <0.05).Conclusion:Mi-crowave ablation combined with radiochemotherapy can more effectively kill lung cancer cells,induce cell apoptosis and autoph-agy,and inhibit MMPs expression and EMT process.关键词
肺癌/微波消融术/凋亡/上皮-间叶细胞转化/自噬Key words
Lung cancer/Microwave ablation/Apoptosis/Epithelial-mesenchymal transition/Autophagy分类
医药卫生引用本文复制引用
张殷..周围型肺癌患者接受微波消融联合放化疗后的肿瘤恶性程度评估[J].海南医学院学报,2016,22(10):992-995,4.基金项目
四川省卫生厅科研课题(120080)[Foundation Project]:This study was supported by Research Project of Sichuan Provincial Health Department (No ．120080)． （120080）
