海南医学院学报2016，Vol.22Issue(10)：1007-1008,1011,3.DOI:10.13210/j.cnki.jhmu.20160125.007
乌司他丁对体外循环心脏手术患者心肌酶谱、炎性状态的影响
Influence of ul inastatin on myocardial enzyme spectrum,inflammatory state and reperfusion injury of patients with extracorporeal circulation heart operation
摘要
Abstract
Objective:To study the influence of ulinastatin on the myocardial enzyme spectrum,inflammatory state and reperfusion injury of patients with extracorporeal circulation heart operation.Methods:A total of 60 patients with extracorporeal circulation heart operation in our hospital from September 2012 to August 201 5 were the research object,and 60 cases were ran-domly divided into control group(routine operation group)and observation group(routine operation and ulinastatin group)with 30 cases in each.Then the serum myocardial enzyme spectrum,inflammatory indexes and related indexes of reperfusion injury of two groups before the operation and at 12 h,24 h and 72 h after the operation were detected and compared.Results:The ser-um myocardial enzyme spectrum indexes of observation group at 12 h,24 h and 72 h after the operation were all significantly lower than those of control group;inflammatory indexes and related indexes were significantly better than those of control group too (P <0.05 for all).Conclusion:The ulinastatin can effectively improve the myocardial enzyme spectrum and inflamma-tory state of patients with extracorporeal circulation heart operation,and it also plays an active role in the prevention and control the reperfusion injury.关键词
乌司他丁/体外循环心脏手术/心肌酶谱/炎性状态/再灌注损伤Key words
Ulinastatin/Extracorporeal circulation heart operation/Myocardial enzyme spectrum/Inflammatory state/Reperfusion injury分类
医药卫生引用本文复制引用
邓明彬,万居易,方易冰..乌司他丁对体外循环心脏手术患者心肌酶谱、炎性状态的影响[J].海南医学院学报,2016,22(10):1007-1008,1011,3.基金项目
四川省自然科学基金(c281123)[Foundation Project]:This study was supported by Natural Science Foundation of Sichuan province (c 281123)． （c281123）
