军事医学2016，Vol.40Issue(2)：147-149,3.DOI:10.7644/j.issn.1674-9960.2016.02.017
GLP体系下比格犬临床病理学指标正常参考值的建立
Establishment of normal reference ranges for clinical pathology indexes of Beagle dogs in GLP system
摘要
Abstract
Objective To establish the normal reference ranges of clinical pathology for Beagle dogs in the Good Laboratory Practice ( GLP ) system.Method Sixteen biochemical indexes , seventeen hematological indexs and three coagulation function indexes of 117 Beagle dogs were detected , and the mean value of each index and the normal reference ranges were calculated and compared .Results Only alkaline phosphatase ( ALP ) from the biochemical items was significantly different between males and females (P<0.01),which was higher among males than among females .Three in-dexes of hematology were significantly different between males and females (P<0.01),with red blood cell(RBC), hemo-globin(HGB)and hematocrit(HCT)lower among males than among females.The coagulation function items were not signif-icantly different between the two sexes .Conclusion Some indexes of clinical pathology were significantly different between males and females , which should be considered during statistic analysis on toxicity .Our study has established the normal reference range of clinical pathology for Beagle dogs in the GLP system , which provides reference for toxicity tests .关键词
比格犬/病理学,临床/参考值/碱性磷酸酶/红细胞/血红蛋白/血细胞比容Key words
Beagle dogs/pathology/clinical/normal reference/alkaline phosphatase/erythrocyte/hemoglobin/hem-atocrit分类
医药卫生引用本文复制引用
贾栗,王以美,张利军,李利忠,彭双清..GLP体系下比格犬临床病理学指标正常参考值的建立[J].军事医学,2016,40(2):147-149,3.基金项目
国家973计划资助项目(2011CB503803) （2011CB503803）
