军事医学2016，Vol.40Issue(2)：158-161,4.DOI:10.7644/j.issn.1674-9960.2016.02.020
TWEAK及其受体在心血管疾病中的作用研究进展
Research progress in TWEAK and its receptor functions in cardiovascular diseases
摘要
Abstract
Tumor necrosis factor-like weak inducer of apoptosis ( TWEAK ) is a member of the superfamily .TWEAK binds to its receptor [ fibroblast growth factor-inducible 14 ( Fnl4 ) and the serum level of soluble CD 163 ( sCD163 ) ] and regulates many cellular activities via associated signal pathways ,including proliferation,migration,differentiation,apoptosis, angiogenesis and inflammation ,which play a significant role in the formation and development of cardiovascular diseases , such as atherosclerosis , heart failure , cardiomyopathy , and peripheral vascular disease .This review summarizes functions of TWEAK and its receptor in cardiovascular diseases .关键词
肿瘤坏死因子样弱凋亡诱导因子/心肌梗死/心力衰竭/心肌病/动脉粥样硬化/外周血管疾病/心肌纤维化Key words
TWEAK/myocardial infarction/heart failure/cardiomyopathy/atherosclerosis/peripheral vascular disease/myocardial fibrosis分类
医药卫生引用本文复制引用
洪长江,李全亮,张园..TWEAK及其受体在心血管疾病中的作用研究进展[J].军事医学,2016,40(2):158-161,4.基金项目
国家自然科学基金资助项目(81402671) （81402671）
