检验医学与临床2016，Vol.13Issue(5)：577-579,3.DOI:10.3969/j.issn.1672-9455.2016.05.001
慢性阻塞性肺疾病抗心磷脂抗体水平分析
Analysis on serum anticardiolipin antibody level in chronic obstructive pulmonary diseases
摘要
Abstract
Objective To investigate the relation between anticardiolipin antibody (ACA ) with chronic ob‐structive pulmonary diseases (COPD) .Methods The ELISA method was adopted to detect the serum ACA IgG /A /M levels in 103 cases of COPD and 72 healthy controls .The COPD group was subdivided into the ACA positive sub‐group and ACA negative subgroup .The relation between the gender ,age and body mass index (BMI) with the lung function indexes was compared between the ACA positive and negative patients .Results In the qualitative angle , ACA positive rates in the COPD group and the healthy control group were 16 .5% (17/103) and 4 .2% (3/72) respec‐tively ,showing the statistical difference between them (P< 0 .05) ,in the staging by the Global Initiative for Chronic Obstructive Pulmonary Disease(GOLD) ,the ACA positive rates in the stage Ⅰ - Ⅳ were in turn 66 .7% ,18 .5% , 13 .9% and 3 .2% ,which were gradually declined .In the quantitation angle ,the ACA concentration in the ACA group was (4 .4 ± 0 .7)RU /mL ,which was much higher than (2 .6 ± 0 .4) RU /mL in the healthy control group (P< 0 .05) ;which in the GOLD stage Ⅰ - Ⅳ were (10 .9 ± 2 .6) ,(3 .9 ± 1 .0) ,(4 .8 ± 1 .4) ,(2 .5 ± 0 .6)RU /mL respectively .The COPD patients with ACA positive were mainly concentrated at the GOLD stage Ⅰ ,the ACA positive rate and con‐centration at the GOLD stage Ⅰ were much higher than those in the other GOLD stages .The ACA positive had no obvious association with the gender ,age and BMI in the COPD patients (P> 0 .05) .Conclusion ACA has an associa‐tion with the GOLD stage in COPD and mainly appears at the early stage of the disease .ACA may be used as a novel marker in the early diagnosis of COPD and may play certain role in the pathogenesis of COPD .关键词
抗心磷脂抗体/慢性阻塞性肺疾病/慢性阻塞性肺疾病全球倡议Key words
anticardiolipin antibody/chronic obstructive pulmonary diseases/global initiative for chronic obstructive lung disease引用本文复制引用
程贵莲,熊银,张念,崔天盆..慢性阻塞性肺疾病抗心磷脂抗体水平分析[J].检验医学与临床,2016,13(5):577-579,3.基金项目
国家自然科学基金面上项目（81170035）；湖北省自然科学基金项目（2010CDB08903）。 （）
