检验医学与临床2016，Vol.13Issue(5)：638-640,643,4.DOI:10.3969/j.issn.1672-9455.2016.05.024
鲍曼不动杆菌耐药性变迁分析及临床对策
Analysis on drug resistance change of Acinetobacter baumannii and clinical countermeasures
马玲 1叶扬 1郭炜1
作者信息
- 1. 新疆维吾尔自治区昌吉回族自治州人民医院检验科，新疆昌吉 831100
- 折叠
摘要
Abstract
Objective To understand the flora distribution and the change trend of antimicrobial drug resist‐ance of Acinetobacter baumannii (ABA) to provide the experimental basis for clinical prevention ,diagnosis ,treatment and reasonable application of antimicrobial agents in clinical anti‐infection .Methods The distribution and drug resist‐ance situation of ABA isolated from the various kinds of clinically submitted specimens in our hospital from January 2011 to December 2014 were performed the retrospective analysis .The VITEK2 compact automatic identification in‐strument was used to identify the bacterial strains and conduct the drug susceptibility test .The results were statisti‐cally analyzed .Results Among 7 136 strains of pathogenic bacteria were isolated from the various kinds of specimens during these 4 years ,in which 300 strains were ABA with the isolation rate of 4 .2% ,117 strains were multi‐drug re‐sistant ABA (MDR‐AB) ,the separation rate was 39 .0% ,13 strains were pan‐drug resistant ABA (PDR‐AB) ,the separation rate was 4 .3% ,the separation rate showed the upward trend as a whole .The ABA clinical distribution was dominated by ICU (31 .7% ) ,followed by the respiration department (29 .3% ) ,and the scattered distribution was in other departments .The infection distribution was mainly in respiratory tract specimens ,followed by the secretion specimens ,accounting for 89 .7% and 4 .3% respectively .Most of resistance rates of ABA to commonly used antimi‐crobial agents were more than 40% ,ABA showed the higher resistance to penicillins ,cephalosporin and beta lactam antimicrobial agents .The resistance rate to amikacin was lowest (3 .0% ) and ABA was completely resistant (100% ) to cefotetan and cefuroxime sodium .Conclusion ABA generates higher resistance to many kinds of antimicrobial a‐gents ,moreover the multi‐drug resistant and pan‐drug resistant phenomena are serious ,so the dynamic monitoring its drug resistance should be strengthened ,the rational use of antimicrobial drugs should be standardized ,the aseptic op‐eration should be strictly implemented for controlling and delaying the generation of multi‐drug resistant and pan‐drug resistant strains ,preventing and controlling the infection and epidemic outbreak of ABA .关键词
鲍曼不动杆菌/抗菌药物/多药耐药/泛耐药Key words
Acinetobacter baumannii/antibacterial drug/multi-drug resistant/pan-drug resistant引用本文复制引用
马玲,叶扬,郭炜..鲍曼不动杆菌耐药性变迁分析及临床对策[J].检验医学与临床,2016,13(5):638-640,643,4.
