中国临床保健杂志2016，Vol.19Issue(1)：19-21,3.DOI:10.3969/J.issn.1672-6790.2016.01.006
依达拉奉治疗急性脑出血的疗效分析
Effects of edaravone for treating acute intracerebral hemorrhage
摘要
Abstract
Objective To explore the influence of edaravone for serum TNF-αand IL-1 and effects of in a-cute intracerebral hemorrhage.Mehtods Ninety cases with acute intracerebral hemorrhage were randomly divided into two groups:45 cases were treated with conventional therapy as control group,45 cases were treated with edaravone 30 mg and 0.9% NS 100 mL iv gtt,bid for 14 days as treatment group.The neurological impairment score (NIHSS)and activi-ty of daily living(ADL)scale were evaluated and compared before and after treatment between two groups.The changes of TNF -αand IL-1 were detected before and after treatment between two groups.Results The NIHSS and ADL of treatment group were higher than those of control group 14 days later(P <0.05).The clinical effect of treatment group was significantly better than control group (P <0.05).Both neurological impairment score and capability of daily living were improved obviously.Serum TNF-αand IL-1 in treatment group were significantly decreased compared with control group after treatment(P <0.05).Conclusion Edaravone can alleviate inflammatory reaction,eliminate free radicals, improve the symptoms of neurological impairment for acute intracerebral hemorrhage.关键词
脑出血/自由基清除剂/肿瘤坏死因子 α/白细胞介素 1Key words
Cerebral hemorrhage/Free radical scavengers/Tumor necrosis factor-alpha/Interleukin-1分类
医药卫生引用本文复制引用
沈琪琦,张之龄,童小文,王伟..依达拉奉治疗急性脑出血的疗效分析[J].中国临床保健杂志,2016,19(1):19-21,3.基金项目
上海高校青年教师培养资助基金 （）
