四川精神卫生2016，Vol.29Issue(1)：10-13,4.DOI:10.11886/j.issn.1007-3256.2016.01.003
双相I型障碍抑郁发作患者血清尿酸水平及其影响因素
Study on the level and relative factors of serum uric acid in the patients with depressive episodes of bipolar I disorder
摘要
Abstract
Objective To explore the serum levels of uric acid( UA)and relative factors in the patients with depressive episodes of bipolar I disorder. Methods The case - control study was used for the investing. A total of 68 inpatients with depressive episodes of bipolar disorder( patient group)and 68 healthy individuals( control group)were enrolled. Serum levels of UA was measured by automatic biochemical analyzer. Hamilton Depression Scale(HAMD)was used to evaluate the severity of depression. Results The prevalence rate of hyperuricemia(HUA)was 20. 6% in the patient group and 7. 4% in the control group(P ﹤ 0. 05). There was a statistical difference in serum UA levels between the patient group and the control group[(310. 31 ± 83. 35)μmol/ L vs. (282. 47 ± 78. 30)μmol/ L,P ﹤0. 05],and serum UA levels was higher in men than in women in the patient group[(344. 40 ±100. 45)μmol/ L vs.(296. 10 ± 71. 59)μmol/ L,P ﹤ 0. 05]. Correlation analysis showed gender and positive family history of mental illness had negatively correlation(r = - 0. 28,- 0. 27,P ﹤ 0. 05)and triglyceride had positive correlation(r = 0. 34,P ﹤ 0. 01)with serum levels of UA. Stepwise multiple regression analysis showed gender and positive family history of mental illness were associated with serum levels of UA among the patients(P ﹤ 0. 01). Conclusion The serum UA levels in the patients with depressive episodes of bipolar I disorder increases,which is associated with gender,positive family history of mental illness.关键词
双相障碍/抑郁发作/尿酸/高尿酸血症Key words
Bipolar disorder/Depression/Uric acid/Hyperuricemia分类
医药卫生引用本文复制引用
陈红梅,陈景旭,梁雪梅,刘可智,王璇,张立刚,王绍礼..双相I型障碍抑郁发作患者血清尿酸水平及其影响因素[J].四川精神卫生,2016,29(1):10-13,4.基金项目
首都临床特色应用研究 （）
