四川精神卫生2016，Vol.29Issue(1)：14-18,5.DOI:10.11886/j.issn.1007-3256.2016.01.004
中国汉族人群双相障碍不同疾病状态下的氧化应激损害
Oxidative stress damage in different phases of bipolar disorder in Chinese Han population
摘要
Abstract
Objective To explore differences of oxidative stress damage among different phases in patients with bipolar disorder. Methods Fifty - three patients with bipolar I disorder and 59 healthy controls(HC)were recruited in Guangzhou Huiai Hospital. Hamilton Depression Scale - 17 item(HAMD - 17)and Bech - Rafaelsen Mania Rating Scale(BRMS)were used to assess the clinical symptoms. Peripheral blood were collected in the early morning and used to test the contents of superoxide dismutase (SOD),glutathione peroxidase(GPx)and Malonaldehyde(MDA)in all participants. Results ①The contents of MDA(F = 8. 362, P ﹤ 0. 01)and GPx(F = 4. 550,P = 0. 013)in patients were higher than HC. ②Patients were divided into manic group(MA)and depressive group(DP)according to the clinical symptoms. There were significant differences in MDA among the MA,DP and HC (F = 6. 079,P ﹤ 0. 01). MDA in MA and DP were higher than HC,respectively(P ﹤ 0. 01). The differences of GPx were significant among the three groups(F = 3. 355,P = 0. 022). GPx in DP was higher than HC(P = 0. 012). ③Patients were divided into psychotic group(Ps)and non - psychotic group(NPs)according to the psychotic symptoms. There were significant differences in MDA among the Ps,NPs and HC(F = 5. 646,P = 0. 001). MDA in Ps and NPs were higher than HC,respectively(P ﹤ 0. 05 或 0. 01). The differences of GPx were significant among the three groups(F = 4. 356,P ﹤ 0. 01). GPx in Ps was higher than HC(P ﹤ 0. 01). ④There were no significant association between age of episode,counts of inpatient,duration of illness,HAMD and BRMS with SOD, GPx and MDA,respectively(P ﹥ 0. 05). Conclusion There is oxidative stress system disturbance in the episode phrase of patients with bipolar disorder,which may be associates with the clinical characters.关键词
双相障碍/氧化应激/抗氧化酶Key words
Bipolar disorder/Oxidative stress/Antioxidant enzyme分类
医药卫生引用本文复制引用
李烜,李含秋,张晓菲,杨婵娟,成雄超,郑朝盾,曹莉萍,林鄞..中国汉族人群双相障碍不同疾病状态下的氧化应激损害[J].四川精神卫生,2016,29(1):14-18,5.基金项目
广州市医药卫生科技项目（20141A011042）；广州市医学重点学科项目 （）
