现代妇产科进展2016，Vol.25Issue(1)：22-24,28,4.DOI:10.13283/j.cnki.xdfckjz.2016.01.031
氧化再生纤维素防粘连膜在重度宫腔粘连治疗中的作用及其对转化生长因子β1表达的影响
The effects of oxidized regenerated cellulose in treatment of severe intrauterine adhesion ;and expression of transforming growth factor-β1
摘要
Abstract
Objective:To evaluate the possible mechanisms of pathogenesis of severe intrauterine adhesions ( IUA) ,the effects of oxidized regenerated cellulose ( ORC) in treatment of severe IUA and expression of transforming growth factor-β1 ( TGF-β1 ) . Methods:60 pa-tients with severe IUA were randomly divided into the observation group (30 patients) and the control group (30 patients) . After operation,intrauterine device ( IUD) and ORC were inserted into uterine cavity in the observation group,while the control group used IUD only. All cases underwent postoperative artificial cycles for successive 3 months and the second-look hysteros-copy. The expression of TGF-β1 in the fibrosis tissue and the normal endometrium were mesured by immunohistochemistry method. Results:Before operation,the expression of TGF-β1 in the fibrosis tissue was significantly higher than that in the normal endometrium ( P<0 . 01 ) . In each groups,the postoperative expression of TGF-β1 was significantly higher than before op-eration in the normal endometrium and also in the fibrosis tissue (P<0. 01). After operation, TGF-β1 of the observation group was significantly lower than that of the control group in the fi-brosis tissue ( P<0 . 01 ) . The total effective rate of the observation group was significantly higher than that of the control group(P<0. 05). In re-adhesion cases,the degree of adhesion was sig-nificantly lower in observation group than that in control group ( P<0 . 05 ) . Conclusions:The abnomal expression of TGF-β1 may be relavant to the occurrence of severe IUA,ORC could im-prove the effective rate,downgrade the degrees of re-adhesion and decrease expression of TGF-β1.关键词
宫腔粘连/氧化再生纤维素防粘连膜/转化生长因子β1/免疫组织化学Key words
Intrauterine adhesion/Oxidized regenerated cellulose/Transforming growth factor-β1/Immunohistochemistry分类
医药卫生引用本文复制引用
曾薇薇,姚吉龙,史文娟,唐国玲..氧化再生纤维素防粘连膜在重度宫腔粘连治疗中的作用及其对转化生长因子β1表达的影响[J].现代妇产科进展,2016,25(1):22-24,28,4.基金项目
深圳市医疗卫生类科技项目(No:201303082) （No:201303082）
