现代妇产科进展2016，Vol.25Issue(1)：25-28,4.DOI:10.13283/j.cnki.xdfckjz.2016.01.006
补体活化对SLE孕妇胎儿不良结局影响的研究
The study of relationship between complement activation and SLE fetal adverse out-come
摘要
Abstract
Objective:To investigate the relationship between autoantibodies mediated complement activation and adverse pregnancy outcomes,to improve the outcome of pregnancy. Methods:Placenta pathology and immunohistochemistry of C1 q and C4 d were compared be-tween 16 placentas of pregnant women with SLE and 20 placentas of normal pregnant women accepted in Fujian Provincal Hospital from 2011 Jan. to 2013 Jan. Results:16 placentas of pregnant women with SLE were found degeneration of villus, partly infartion, thrombopoiesis, partly calcification and acute or chronic inflammatory cell infiltration. C4d diffuse staining was found in maternal-fetal junction of 9 SLE pregnancies with 7 non-guidance-pregnancy (77.8%),2 guidance-pregnancy (22. 2%),5 FGR (55. 6%) and 6 preterm delivery (66. 7%). C4d focal dyeing was found in 7 pregnancies,which were higher than control group. There was no statistical difference about placentas immunohistochemistry of C1 q staining be-tween two groups. Conclusions:The excessive deposition of C4d in maternal-fetal junction of SLE pregnancies was associated with poor neonatal outcome,for non-guidance-pregnancy spe-cially,C4d counld be seemed as a biomarker for autoantibodies mediated adverse fetal outcome and as evidence to improve outcome of secondary pregnancy.关键词
妊娠/系统性红斑狼疮/妊娠结局/胎盘病理/免疫组化Key words
Pregnancy/SLE/Outcome of pregnancy/The pathology of placenta/Immu-nohistochemistry分类
医药卫生引用本文复制引用
沈明虹,杨茵,孙阳,林靓,林晶,陈燕萍..补体活化对SLE孕妇胎儿不良结局影响的研究[J].现代妇产科进展,2016,25(1):25-28,4.基金项目
福建省卫生厅青年科研基金(No:2014-1-10) （No:2014-1-10）
