现代妇产科进展2016，Vol.25Issue(1)：47-49,3.DOI:10.13283/j.cnki.xdfckjz.2016.01.011
曲普瑞林预防环磷酰胺对系统性红斑狼疮患者卵巢储备功能医源性损害的临床比较研究
Ovarian reserve of SLE patients treated by triptorelin combined with cyclophosphamide
摘要
Abstract
Objective:To study the short-term protection of Gonadotropin-releasing hor-mone agonist ( GnRHa) triptorelin combined with cyclophosphamide ( CTX) in the ovarian re-serve of systemic lupus erythematosus ( SLE) patients,and to preliminarily evaluate the effec-tiveness of GnRHa as ovarian protection in the treatment of CTX on SLE. Methods:A total of 27 SLE fertile patients with first six-month of CTX treatment were analyzed in the Department of Rheumatology and Immunology of Peking University Shenzhen Hospital from Mar. 2013 to Mar. 2015. According to the use of GnRHa,the patients were divided into the CTX combined with GnRHa group (CTX+GnRHa,n=12) and CTX only group (CTX,n=15). ELISA assay was used to compare AMH changes pre- and post-treatments between the two groups. Results:No significance was found in the AMH levels before the treatment between the CTX+GnRHa and CTX groups (2. 42±0. 85 and 2. 39±0. 88). However,the level of AMH in the CTX+GnRHa group was significantly higher than that in the CTX group (1. 99±0. 56 and 1. 31±0. 48). The post-treatment level of AMH was similar to that in the pre-treatment of CTX+GnRHa in two groups,while a significance was found between the pre-and post-treatment of CTX group. Con-clusion:GnRHa can help protect ovarian reserve of SLE patients in the CTX treatment.关键词
红斑狼疮,系统性/环磷酰胺/卵巢保护/促性腺释放激素类似物Key words
Lupus erythematosus/Systemic/Cyclophosphamide/Ovarian reserve/Gon-adotropin-releasing hormone analog分类
医药卫生引用本文复制引用
魏蔚霞,林琦,黄倩羽,王庆文,吴瑞芳..曲普瑞林预防环磷酰胺对系统性红斑狼疮患者卵巢储备功能医源性损害的临床比较研究[J].现代妇产科进展,2016,25(1):47-49,3.基金项目
广东省深圳市科技研发资金项目(No:JCYJ20130402114317405) （No:JCYJ20130402114317405）
