摘要
Abstract
Objective To explore the effectiveness of vitamin D ( VD ) supplement and to evaluate the bone metabolism indexes of preterm infants by follow-up.Methods A total of 60 preterm infants who were hospitalized in the neonatal intensive care unit ( NICU) of Peking University Shenzhen Hospital from June to December in 2014 were enrolled.We recorded their gender, gestational age, birth weight, head circumference and height, and detected the levels of serum osteocalcin ( OC) , 25 ( OH) D3 , calcium and phosphorus.When the infants could be orally fed 〔averagely ( 6.4 ±2.3 ) days after birth〕, VD supplement was given by 800 U/d.After 28-day follow-up, the indexes mentioned above were detected again and compared with those at birth.Results The serum 25 (OH) D3 level of these 60 preterm infants at birth was (17.0 ±7.0) μg/L, and the serum OC level was ( 81.6 ±31.6 ) μg/L.VD deficiency ( VDD ) occurred in 43 ( 71.7%) infants, and the lack of VD supplement during their mothers′pregnancy was a risk factor for VDD in these infants 〔OR=6.83, 95%CI (1.66, 27.99)〕.After regular addition of VD supplement, 37 preterm infants were significantly higher in weight, height, head circumference and serum calcium level on the 28th day after birth than those at birth (P<0.05), but they saw no significant changes in serum phosphate, 25 (OH) D3 and OC levels (P>0.05) .On 28th day after birth, 28 infants still had VDD among the 37 infants, and hypophosphatemia (serum phosphate <1.8 mmol/L) was found to be a risk factor for VDD 〔OR=7.33, 95%CI (1.40, 38.34)〕 .Conclusion The VD supplement by 800 U/d can not effectively improve the bone metabolism of infants and reverse VD deficiency.The monitor of the levels of 25 ( OH ) D3 , OC and phosphorus can reflect the status of bone metabolism of preterm infants.关键词
婴儿,早产/维生素D/骨化二醇/维生素D缺乏/骨钙素/血清钙/血清磷Key words
Infant, premature/Vitamin D/Calcifediol/Vitamin D deficiency/Osteocalcin/Serum calcium/Serum phosphate分类
医药卫生
