中国全科医学2016，Vol.19Issue(8)：869-872,4.DOI:10.3969/j.issn.1007-9572.2016.08.001
HIV 感染者和 AIDS 患者外周血 T淋巴细胞活化亚群与病毒载量的相关性
Correlation Between Peripheral Blood Tlymphocyte Activation Subgroup and Viral Load in HIV/AIDS Patients
摘要
Abstract
Objective To investigate the correlation between peripheral blood T lymphocyte activation subgroup expression and viral load in HIV/AIDS patients.Methods From June to August in 2012, we selected 322 HIV-infected patients and 87 AIDS patients from an AIDS high-prevalence area in Henan Province.Peripheral blood T lymphocyte and its activation subgroup and plasma viral load of HIV-infected patients and AIDS patients were detected respectively using flow cytometry and full-automatic viral load instrument.According to viral load level, we divided the subjects into Ⅰ-Ⅳ group. Results HIV-infected patients and AIDS patients were not significantly different in the relative value of CD3+T cell and CD2+8/CD4+ ( P>0.05 ) .HIV-infected patients were higher in the absolute and relative value of lymphocyte, the absolute value of CD3+T cell, the absolute value of CD3+CD8+T cell, the absolute and relative value of CD3+CD4+T cell and the absolute value of CD3+CD4+CD8+T cell and lower in the relative value of CD3+CD8+T than AIDS patients ( P<0.05 ); HIV-infected patients were higher in the ratio of helper T cell and suppressor T cell ( H/S) and CD2+8/CD8+and lower in CD3+8/CD8+than AIDS patients ( P<0.05) .The four groups were significantly different in the absolute value and relative value of lymphocyte, the relative value of CD3+T cell, the relative value of CD3+CD8+T cell, the absolute and relative value of CD3+CD4+T cell, H/S, CD2+8/CD4+, CD2+8/CD8+and CD3+8/CD8+ ( P<0.05 ) .The relative value of CD3+T cell , relative value of CD3+CD8+T cell and CD3+8/CD8+, were positively correlated with the viral load level ( rs =0.128, 0.291, 0.409; P <0.05) .The absolute and relative value of CD3+CD4+T, and H/S、 CD2+8/CD4+、 CD2+8/CD8+were negative correlated with the viral load level ( rs =-0.246, -0.318,-0.297, -0.184, -0.204; P <0.05).Conclusion There are changes in the activated process of T lymphocyte in HIV-infected and AIDS patients; with the change of viral load level, difference occurs between HIV-infected and AIDS patients in the level of T lymphocyte activation subgroup.关键词
获得性免疫缺陷综合征/HIV/T淋巴细胞亚群/病毒载量Key words
Acquired immunodeficiency syndrome/HIV/T-lymphocyte subsets/Viral load分类
医药卫生引用本文复制引用
李强,李杰,桑锋,刘真,岳静宇,沈俊岭,钱洁玉,何书杰,徐立然..HIV 感染者和 AIDS 患者外周血 T淋巴细胞活化亚群与病毒载量的相关性[J].中国全科医学,2016,19(8):869-872,4.基金项目
国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项“十二五”计划课题(2012ZX10004905-003-003，2012ZX10005010-001）；国家中医药管理局临床科研基地科研专项( JDZX2012023）；河南省高等学校青年骨干教师资助计划(2013GGJS-095）；河南省基础与前沿计划项目(132300413215） （）
