中国全科医学2016，Vol.19Issue(8)：894-897,4.DOI:10.3969/j.issn.1007-9572.2016.08.006
脓毒症性急性肾损伤患者 CD4+ T淋巴细胞内三磷酸腺苷水平变化及其与肾功能转归的关系
Changes of CD4+T Cell Intracellular ATP Level of Patients With Septic Acute Kidney Injury and Its Relation With Renal Function Outcome
朱潮涌 1李洁 1毛明锋 1黄甘霖 1鲍晓红 1金烈1
作者信息
摘要
Abstract
Objective To investigate the value of CD4+T cell-iATP level in the prediction of the prognosis of sepsis patients complicated with acute kidney injury ( AKI).Methods From July 2013 to December 2014, a total of 69 sepsis inpatients complicated with AKI in the ICU, the Department of Infectious Disease and Nephrology in Lishui Center Hosipital were enrolled in this prospective study.The levels of CD4+T cell-iATP at 0 h, 48 h and 96 h after onset of SIAKI were detected.According to the prognosis of acute kidney injury ( AKI) , the subjects were divided into four groups: complete renal recovery group (18 cases), partial renal recovery group (38 cases), dialysis dependency group (4 cases) and death group (9 cases) .Results The four groups were significantly different in estimated glomerular filtation rate ( eGFR ) , the number of visceral organs with function failure, and numbers of patient in each stage of AKI and the levels CD4+T cell-iATP at 0 and 48 h (P<0.05).Multivariable Logistic regression analysis indicated that eGFR, the number of visceral organ with function failure and the levels of CD4+T cell-iATP (48 h) were influencing factors for the complete recovery and partial recovery of renal function (P<0.05), compared with unfavorable prognosis (dialysis dependency or death) .ROC curve analysis showed that the AUC of CD4+T cell-iATP (48 h) predicting the prognosis of sepsis patients complicated with AKI was 0.926 (P <0.01), with a sensitivity and a specificity as 92.3%and 87.5% respectively at a critical point of 344.2 μg/L for CD4+T cell-iATP (48 h) level.Conclusion Sepsis patients with lower CD4+T cell-iATP level have better recovery of renal function, and CD4+T cell-iATP level of patients with early-stage sepsis may serve as a predictor for the renal function outcome.关键词
脓毒症/急性肾损伤/CD4+T淋巴细胞/临床转归Key words
Sepsis/Acute kidney injury/CD4+T lymphocyte/Clinical outcomes分类
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朱潮涌,李洁,毛明锋,黄甘霖,鲍晓红,金烈..脓毒症性急性肾损伤患者 CD4+ T淋巴细胞内三磷酸腺苷水平变化及其与肾功能转归的关系[J].中国全科医学,2016,19(8):894-897,4.
