摘要
Abstract
Objective To explore the differences in experimental pain, postoperative pain and postoperative opioid dosage among Uygur, Hazak and Han ethnic groups in Xinjiang Uygur Automonous Region.Methods In this prospective study, we enrolled 93 patients who underwent radical resection of rectal carcinoma from August 2013 to October 2014, among which 32 patients were Uyghur people, 31 patients were Kazak people and 30 patients were Han people.Pressure pain threshold ( PPT) and pressure pain tolerance ( PTO) were measured before surgery by portable pressure tester 2 cm above the horizontal stripes on the inner side of the wrist of the right arms of the patients.Intravenous patient controlled analgesia ( PCA ) was performed within 48 hours after surgery.Visual analogue scale ( VAS ) scores were recorded 6 h, 12 h, 24 h and 48 h after surgery.VAS score >4 was recorded as inadequate analgesia, and 40 mg parecoxib was given by intravenous vein immediately.The occurrence of adverse reactions ( nausea, vomit, pruritus and respiratory depression ) and the dosage of sufentanil in PCA pump when analgesia ended were recorded.Results There was no statistically significant differences in PPT among the three ethnic groups (P>0.05).Significant differences existed in PTO among the three ethnic groups (P<0.05);Kazak patients and Han patients were higher than Uygur patients in PTO (P<0.05).There was no interaction between ethnic group and postoperative time (P>0.05); and there was statistically significant difference on VAS score among three groups (P<0.05); Kazak patients and Han patients were lower than Uygur patients in VAS score 6 hours after operation (P<0.05). Different ethnic groups were significantly different in the dosage of sufentanil and the proportion of incomplete analgesia ( P<0.05); Kazak patients and Han patients were lower than Uygur patients in the dosage of sufentanil and the proportion of incomplete analgesia ( P <0.05 ) . Vomit occurred in 7 ( 21.9%) Uygur patients, 6 ( 19.4%) Kazak patients and 6 (20.0%) Han patients, with no significant differences among them (χ2 =0.07, P=0.96).PTO of the three ethnic groups was negatively correlative with VAS score 6 hours and 12 hours after operation ( P<0.05 ) , while PPT and PTO had no linear correlation with the dosage of sufentanil (P>0.05).Conclusion Differences exist in experimental pain, postoperative pain and postoperative opioid dosage between Uygur patients and Kazak and Han patients.Preoperative PTO may help to predict postoperative pain severity.关键词
疼痛/人种群/痛阈/镇痛药, 阿片类/维吾尔族Key words
Pain/Ethnic groups/Pain threshold/Analgesics, opioid/Uyghur nationality分类
医药卫生
