中国全科医学2016，Vol.19Issue(9)：1021-1023,1031,4.DOI:10.3969/j.issn.1007-9572.2016.09.007
慢性丙型病毒性肝炎伴发焦虑抑郁症患者血清载脂蛋白B的表达水平及意义研究
Expression and Value of Serum Apolipoprotein B in Patients With Chronic Hepatitis C Accompanied by Anxiety and ;Depressive Disorder
摘要
Abstract
Objective To investigate the apolipoprotein B ( Apo B) level and its significance of patients with chronic hepatitis C ( CHC) accompanied by anxiety or depressive disorder.Methods A total of 100 CHC patients who were hospitalized in Dazhou Central Hospital of Sichuang Province from January 2010 to June 2014 were enrolled in CHC group and 100 healthy people determined by physical examination in the same hospital and the same period were enrolled as control group.The degrees of anxiety and depressive disorder were assessed by hospital anxiety and depression scale, and Apo B level was detected by fully automatic biochemical analyzer of Olympus 3200 type.Apo B level was compared among control group and CHC subgroups with different degrees of anxiety or depressive disorder.Results Among the 100 CHC patients, non anxiety group had 54 patients, mild anxiety group had 20 patients and moderately severe anxiety group had 26 patients; non depressive disorder group had 74 patients, mild depressive disorder group had 9 patients and moderately severe depressive disorder group had 17 patients.The serum Apo B levels of non anxiety group, mild anxiety group and moderately severe anxiety group were lower than those of control group (P<0.05); the differences in serum Apo B levels among non anxiety group, mild anxiety group and moderately severe anxiety group were not significant ( P >0.05 ) .The serum Apo B levels of non depressive disorder group, mild depressive disorder group and moderately severe depressive disorder group were lower than those of control group ( P<0.05 ); the serum Apo B levels of mild depressive disorder group and moderately severe depressive disorder group were lower than those of non depressive disorder group ( P<0.05); the serum Apo B level of moderately severe depressive disorder group was lower than that of mild depressive disorder group ( P<0.05 ) .Conclusion Anxiety and depressive disorder in CHC patients is related to the decrease of serum Apo B level and the decrease of serum Apo B level is related to the degree of depressive disorder but is not related to the degree of anxiety.关键词
肝炎, 丙型, 慢性/焦虑/抑郁症/载脂蛋白B类Key words
Hepatitis C, chronic/Anxiety/Depressive disorder/Apolipoproteins B分类
医药卫生引用本文复制引用
王晓,牟君,杨泽松..慢性丙型病毒性肝炎伴发焦虑抑郁症患者血清载脂蛋白B的表达水平及意义研究[J].中国全科医学,2016,19(9):1021-1023,1031,4.基金项目
国家自然科学基金面上项目（81371310）；重庆市卫生局面上项目 （）
