中国全科医学2016，Vol.19Issue(9)：1024-1027,4.DOI:10.3969/j.issn.1007-9572.2016.09.008
基因检测在指导非小细胞肺癌化疗中的作用
Effect of Gene Detection on Guidance of Chemotherapy of Non-small Cell Lung Cancer
摘要
Abstract
Objective To explore the effect of gene detection related with non-small cell lung cancer on the guidance of chemotherapy.Methods A total of 60 patients with non-small cell lung cancer in Tianjin People Hospital from January 2013 to March 2015 were enrolled.The patients were divided into observation group and control group with 30 patients in each group according to the simple random sampling.Nucleotide excision repair cross complementation gene 1 and nucleotide reductase subunit M1 of patients in observation group were detected by immunohistochemistry.Chemotherapy regimens were made according to the expression of the two molecular markers.Patients in control group was cured by cis-platinum combined with docetaxel or gemcitabine.The total effective rate, survival time, progress -free survival and toxic and side effect of the two groups were observed.Results The total effective rate of chemotherapy in the observation group 〔56.7% (17/30)〕 was higher than that in control group 〔30.0% ( 9/30 )〕 (χ2 =6.278, P =0.043 ) .The median survival time of patients in observation group (252 d) was higher than that in control group (225 d) (χ2 =6.327, P=0.031); the median progress-free survival of patients in observation group (172 d) was higher than that in control group (128 d) (χ2 =6.651, P=0.023) .The abnormity of hepatic and renal function, gastrointestinal reaction, the occurrence rate of hematotoxicity between the two groups were not significantly different ( P>0.05) .Conclusion The expression levels of nucleotide excision repair cross complementation gene 1 and nucleotide reductase subunit M1 are closely related with the result of chemotherapy of non-small-cell lung cancer and may become important indexes for the guidance of the chemotherapy.关键词
癌, 非小细胞肺/基因检测/治疗/治疗结果Key words
Carcinoma, non-small-cell lung/Genetic testing/Therapy/Treatment outcome分类
医药卫生引用本文复制引用
唐琼,赵辉,王妍,贾锐,姜春阳..基因检测在指导非小细胞肺癌化疗中的作用[J].中国全科医学,2016,19(9):1024-1027,4.基金项目
国家自然科学基金青年项目（81302824）；天津市应用基础及前沿技术研究计划 （）
