中国现代医学杂志2016，Vol.26Issue(4)：29-32,4.DOI:10.3969/j.issn.1005-8982.2016.04.006
核因子E2相关因子2在肺腺癌中的表达及临床意义
Expression and clinical significance of Nrf2 in pulmonary adenocarcinoma
冯稳 1张冰 1于庆凯1
作者信息
- 1. 郑州大学附属肿瘤医院 河南省肿瘤医院 病理科，河南 郑州 450003
- 折叠
摘要
Abstract
Objective To study the expression and clinical significance of signal molecule Nrf2 in pulmonary adenocarcinoma tissues. Methods 88 tissue samples of pulmonary adenocarcinoma and 20 normal lung tissues were collected as research subject. The expressions of Nrf2 in lung tissues were identified by immune histochemistry. Results The positive expression rate of Nrf2 was less than 10 %in normal lung tissue, while it was 69.3 %in tissue samples of pulmonary adenocarcinoma, and 73.3 % in samples combined with metastasis of lymph nodes. The positive expression rate of Nrf2 was higher in poorly differentiated group (84.6 %) than that in middle (76.4 %) and high differentiation group (70.7 %). Conclusion The expression of Nrf2 was upregulated in tissues of pulmonary adnocarcinoma, and it was related with the degree of differentiation and lymph node metastasis of lung adenocarcinoma.关键词
肺/腺癌/Nrf2/免疫组织化学Key words
lung/adenocarcinoma/Nrf2/immune histochemistry分类
医药卫生引用本文复制引用
冯稳,张冰,于庆凯..核因子E2相关因子2在肺腺癌中的表达及临床意义[J].中国现代医学杂志,2016,26(4):29-32,4.
