中国现代医学杂志2016，Vol.26Issue(4)：33-38,6.DOI:10.3969/j.issn.1005-8982.2016.04.007
AEG与钙黏附蛋白E在食管癌中表达的相关性及其意义
Correlationship and significance of AEG1 and expression of E-cad in esophageal carcinoma
赵润根 1张彩凤 1姬娟娟 1张利利 1肖怀葱 1夏永华 2韩宇1
作者信息
- 1. 新乡医学院第一附属医院消化内科，河南 卫辉 453100
- 2. 新乡医学院第一附属医院皮肤科，河南 卫辉 453100
- 折叠
摘要
Abstract
Objective To explore the correlationship of astrocyte elevated gene 1 ( ) and expression of E-cadherin (E-cad) protein in esophageal carcinoma, and analyze its relationship with clinical pathological features. Methods Immunohistochemical and Western Blot test methods were used to detect the expression of and E-cadherin protein in 58 cases of esophageal carcinoma tissues and its corresponding adjacent tissues. Then we analyzed the relationship of , E-cadherin and clinicopathologic correlation. Results In 58 cases of esophageal carcinoma tissues, the positive expression rate of was 82.7 %;The positive expression rate of was 51.7% in the corresponding adjacent tissues, the positive expression rate of in esophageal carcinoma tissues was obviously higher than that in the corresponding adjacent tissues ( < 0.05), and the expression positive rate of in esophageal carcinoma tissues was related to differentiated degree, depth of invasion, clinical stage, and lymph node metastasis ( < 0.05); but no relation with sex, age, tumor site, and pathologic types ( > 0.05); in 58 cases of esophageal carcinoma tissues, the positive expression rate of E-cadherin protein was 31%, the positive expression rate of E-cadherin was 94.8%;the positive expression rate of E-cadherin in esophageal carcinoma tissues was obviously less than that in the corresponding adjacent tissues ( < 0.05); It is related to differentiated degree, depth of invasion, clinical stage, and lymph node metastasis ( < 0.05); but no relation with sex, age, tumor site, and pathologic types ( >0.05); the expression of and E-cadherin protein was significantly negative correlation ( = 0.483, < 0.05). Conclusions The expression of and E-cadherin in esophageal carcinoma was characterized by over-expression and loss-expression, and they were closely associated with invasion and metastasis of esophageal carcinoma, may be mediated E-cadherin less-expression in esophageal carcinoma.关键词
星形细胞上调基因1/钙黏附蛋白E/食管癌/免疫组织化学Key words
astrocyte elevated gene1/E-cadherin/esophageal carcinoma/immunohistochemistry分类
医药卫生引用本文复制引用
赵润根,张彩凤,姬娟娟,张利利,肖怀葱,夏永华,韩宇..AEG与钙黏附蛋白E在食管癌中表达的相关性及其意义[J].中国现代医学杂志,2016,26(4):33-38,6.
