中国现代医学杂志2016，Vol.26Issue(4)：39-43,5.DOI:10.3969/j.issn.1005-8982.2016.04.008
CD24蛋白表达在术后放疗宫颈癌患者预后中的意义
Prognostic significance of CD24 protein expression in cervical carcinoma patients treated with adjuvant radiotherapy after radical hysterectomy
周发为 1杨年红 2游文忠3
作者信息
- 1. 湖北民族学院附属民大医院检验科，湖北 恩施 445000
- 2. 湖北民族学院附属民大医院妇科，湖北 恩施 445000
- 3. 湖北民族学院附属民大医院病理科，湖北 恩施 445000
- 折叠
摘要
Abstract
Objective To evaluate the prognostic significance of CD24 protein overexpression in patients treated with post-operative radiotherapy (RT) after surgery. Methods We determined the CD24 expression status of 140 pa-tients with cervical carcinoma treated with RT alone or with chemoradiotherapy (CRT) after radical hysterectomy procedures. Results CD24 expression was detected in 59 patients (42 %) and was significantly associated with lo-coregional failure-free survival (LRFFS) ( = 0.022), distant metastasis-free survival (DMFS) ( = 0.000), and over-all survival (OS) ( = 0.005). In the multivariate analysis, CD24 positivity was also significantly associated with DMFS ( = 0.025) and OS ( = 0.045). CD24 expression was associated with DMFS ( = 0.000) in the CRT group. However, CD24 expression was associated with LRFFS ( = 0.020) in the RT alone group. Conclusions CD24 ex-pression is an independent prognostic marker in patients with cervical squamous cell carcinoma, even with post-hys-terectomy adjuvant treatment. This study revealed a different prognostic role for CD24 expression in adjuvant CRT and RT alone treatment groups after surgery. New therapeutic strategies targeting CD24 expression stratified by sub-groups might have important clinical implications.关键词
宫颈癌/放疗/化疗/手术/CD24Key words
cervical carcinoma/radiotherapy/chemotherapy/surgery/CD24分类
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周发为,杨年红,游文忠..CD24蛋白表达在术后放疗宫颈癌患者预后中的意义[J].中国现代医学杂志,2016,26(4):39-43,5.
