摘要
Abstract
Objective To investigate the efficacy of Ping-gan-yi-shen decoction in combination with Alprostadil in treatment of vertebra-basilar artery ischemic vertigo and its effects on level of endothelin-1 (ET-1) and calcitonin gene-related peptide (CGRP). Methods Patients of vertebra-basilar artery ischemic vertigo were divided into two groups equally. The control group was treated with Alprostadil, while the observation group was treated with Ping-gan-yi-shen decoction in combination with Alprostadil. Then, the curative efficacy, blood flow velocity of vertebra-basilar artery, serum ET-1 and CGRP were observed and compared. Results The total therapeutic efficacy ratio in the observation group was statistically higher than that in the control group (96.7% vs 86.7%, < 0.05). After the treatment, in comparison with the control group, the observation group had statistically more increased blood flow ve-locity of left vertebral artery, right vertebral artery and basal artery [(33.7 ± 4.5) cm/s vs (28.5 ± 4.3) cm/s, (34.3 ±5.6) cm/s vs (29.2 ±5.1) cm/s, (36.9±6.7) cm/s vs (30.5 ±5.8) cm/s, <0.05]. And the observation group had sta-tistically lower level of ET-1 [(122.5 ± 9.7) ng/L vs (142.3 ± 10.6) ng/L, < 0.05] and higher level of CGRP [(32.2±3.8) ng/L vs (26.9±3.4) ng/L, <0.05] in comparison with the control group. Conclusions Ping-gan-yi-shen de-coction in combination with Alprostadil is effective for vertebra-basilar artery ischemic vertigo, which can significant-ly increase curative efficacy, improve blood supply of vertebra-basilar artery and regulate level of ET-1 and CGRP.关键词
平肝益肾汤/前列地尔/椎-基底动脉供血不足眩晕/内皮素- 1/降钙素基因相关肽Key words
Ping-gan-yi-shen decoction/Alprostadil/vertebra-basilar artery ischemic vertigo/endothelin-1/calcitonin gene-related peptide分类
医药卫生
