摘要
Abstract
Objective To investigate the related factors of liver inflammation activity (G) in patients with hepatitis B associated cirrhosis. Methods 112 patients with hepatitis B associated cirrhosis underwent liver biopsy, blood bio-chemistry detection and quantitative detection of HBV-DNA from August 2011 to October 2014 were selected for this study. According to the results of liver histopathology, patients were divided into G0~G1 group, G2 group and G3~G4 group, and the various clinical indicators among the three groups were compared. The Spearman correlation anal-ysis and multiple regression analysis Logstic were used to analysis the related factors to liver inflammation activity related. Results In 112 cases, 87 cirrhosis patients were only with mild active inflammation (G0~G1, G2), the rate was 77.68 %. Age, platelet count (PLT), prothrombin time (PT), alanine aminotransferase (ALT), aspartate aminotrans-ferase (AST), γ - glutamyl transferase (γ-GT), AST-PLT ratio (APRI), prealbumin (PA), cholinesterase (ChE) and index difference bile acid (TBA) among G0~G1 group, G2 group and G3~G4 group were statistically different ( <0.05).Spearman correlation analysis showed that liver inflammatory activity was positively correlated with age, PT, AST, γ-GT, APRI and TBA ( < 0.05); and negatively correlated with PLT, PA and ChE ( < 0.05). Logistic multivariate analysis showed that age, PT, AST, γ-GT, PA and ChE were the main factors affecting liver inflammatory activity. Conclusions older age, higher serum levels of PT, AST and γ-GT, lower levels of PA and ChE are risk factors liver inflammatory activity in patients with hepatitis B associated cirrhosis.关键词
乙型肝炎病毒/肝硬化/危险因素/病理学Key words
hepatitis B virus/cirrhosis/risk factors/pathology分类
医药卫生
