中国现代医学杂志2016，Vol.26Issue(4)：64-66,3.DOI:10.3969/j.issn.1005-8982.2016.04.013
支气管哮喘患者白细胞介素-33作用的临床研究
Clinical study of interleukin-33 and bronchial asthma
蔡树冰1
作者信息
- 1. 广东省潮州市人民医院 呼吸内科，广东 潮州 521000
- 折叠
摘要
Abstract
Objective To study the changes of plasma interleukin 33 (IL-33) in asthmatic patients and its clinical significance. Methods The objects were collected from March 2013 to March 2015 in our hospital. Including 120 patients with asthma in the acute group, 120 asthma patients in the catabasis group and 80 healthy controls. The plasma levels of IL-33 and immunoglobulin E were detected. The accurate numbers of eosinophil granulocyte (EOS) in peripheral blood were counted. Routine pulmonary function tests were performed in all subjects. Results Com-pared with the healthy controls, the plasma level of IL-33 and Ig E and the numbers of EOS increased in the a-cute attack group ( < 0.05). The plasma level of IL-33 were positively correlated with the level of IgE and the numbers of ESO in the acute attack group ( < 0.05). The plasma level of IL-33 were negatively correlated with FEV1, FEV1/FVC and FEV1% pre in the acute attack group ( < 0.05). Conclusions IL-33 is involved in inflam-mation of asthma. Reducing the plasma level of IL-33 could be a new way to treat asthma.关键词
支气管哮喘/IL- 33/免疫球蛋白E/嗜酸性粒细胞Key words
asthma/IL-33/immunoglobulin E/eosinophil分类
医药卫生引用本文复制引用
蔡树冰..支气管哮喘患者白细胞介素-33作用的临床研究[J].中国现代医学杂志,2016,26(4):64-66,3.
