摘要
Abstract
Objective To study the impact of Ulinastatin on ANP, CYS, KIM-1 in sepsis patients with acute kid-ney injury (AKI). Methods The patients were randomly divided into control group and observation group, control group patients in a timely manner after admission anti-infection, intensive care, breathe, and nutritional support and other conventional treatment; Observation group of patients in the conventional treatment combined Ulinastatin treat-ment, two groups of patients were treated for a period of treatment; Detection of patients with ANP and KIM-1 con-tent in urine samples, blood samples CYS content and the before and after treatment in patients with acute physiolo-gy and chronic health evaluation assessment analysis. Results Control group gradually increased in ANP levels in the urine samples while the observation group in the treatment of the third day after the peak gradually decline, and in the treatment of three days later the statistically significant difference between the two groups ( =2.91 and 8.59,< 0.05); Control group the KIM-1 and CYS levels increases gradually and the observation group in treatment 5 days after the peak gradually decline, and in the treatment of seven days statistically significant difference between the two groups ( = 11.23 and 35.89, < 0.05); In addition, Different time points within two way and different time points between groups compare the ANP, KIM-1 and CYS level are significant differences ( =7.32, 10.16, 5.89 and 19.74, 21.0, 11.63, <0.05); Before and after treatment between two groups of patients with APACHEII there were significant differences ( = 16.04 and 35.49, < 0.05) and also exist significant differences between the two groups after treatment ( = 18.80, < 0.05), but treatment there was no statistically significant difference between the two groups ( = 0.71, > 0.05). Conclusions Ulinastatin on sepsis patients with AKI in ANP, KIM-1 and CYS levelhas certain protective effect on renal injury.关键词
乌司他丁/脓毒症/肾损伤Key words
Ulinastatin/sepsis/kidney injury分类
医药卫生
