中国现代医学杂志2016，Vol.26Issue(5)：7-10,4.DOI:10.3969/j.issn.1005-8982.2016.05.002
丁酸钠对严重烫伤后大鼠肝脏血流量及水肿的影响
Effects of sodium butyrate on hepatic blood flow and tissue edema in rats with severe empyrosis
摘要
Abstract
Objective To investigate the effects of sodium butyrate (BTR) on hepatic blood flow (HBF) and tissue edema in rats following severe empyrosis. Methods Forty-eight male SD rats, weighting (250±10) g, were randomly divided into three groups: normal+BTR (NB) group, empyrosis+normal saline (EN) group and empyrosis +BTR (EB) group. The rats in the EN and EB groups were subjected to 50% TBSA third-degree burns by immersing the back in boiling water for 15 seconds and the abdomen for 8 seconds, and then BTR (400 mg/kg) or normal saline was intraperitoneally injected, respectively. The NB group was intraperitoneally injected with BTR (400 mg/kg). Hepatic blood flow was measured by laser Doppler 3 and 6 hours after injury. Meanwhile, blood was drawn from the heart for measurement of plasma alanine aminotransferase (ALT). The tissue samples of liver were harvested for the measurement of microvascular permeability and tissue water content. Results The plasma level of ALT, the tissue water content and the microvascular permeability of liver significantly increased while the HBF level significantly decreased in the EN group compared with the NB group at 3 and 6 hours after injury. Compared with the EN group, the plasma level of ALT, the microvascu-lar permeability and the tissue water content in the EB group were significantly lowered at 3 and 6 hours af ter empyrosis. In addition, BTR treatment significantly increased the HBF level following empyrosis both at 3 and 6 hours after empyrosis. Conclusions The results indicated that sodium butyrate has significantly pro-tective effects on liver in rats with severe empyrosis by alleviating hepatic edema and increasing blood flow to liver.关键词
丁酸钠/烫伤/肝脏/水肿/谷丙转氨酶Key words
sodium butyrate/empyrosis/liver/tissue edema/ALT分类
医药卫生引用本文复制引用
唐富波,何波,张文华,李雨梦,李静远,胡森..丁酸钠对严重烫伤后大鼠肝脏血流量及水肿的影响[J].中国现代医学杂志,2016,26(5):7-10,4.基金项目
国家自然科学基金 （）
