中国现代医学杂志2016，Vol.26Issue(5)：26-30,5.DOI:10.3969/j.issn.1005-8982.2016.05.006
FOS样抗原2蛋白表达在新疆维吾尔族2型糖尿病中的应用
Expression level of FOSL2 protein in Uygur patients with type 2 diabetes mellitus in Xinjiang
摘要
Abstract
Objective To compare the expression level of Fos-like antigen 2 (FOSL2) protein in Uygur people with type 2 diabetes mellitus (T2DM) and normal glucose tolerance (NGT) in Xinjiang, and analyze the correlation between FOSL2 expression and clinical and biochemical indicators of those subjects. Methods Fifty Uygur adults with T2DM (T2DM group) and fifty with NGT (NGT group) were collected as subjects from October 2013 to October 2014 in Kashi area of Xinjiang. The general clinical indicators were measured and recorded, blood samples were collected at the same time. The metabolic markers such as fasting blood glucose (FPG) and total cholesterol (TC) were measured by clinical chemistry analyzer. The level of fasting insulin (FINS) was measured by automatic chemiluminescence analyzer. Glycosylated hemoglobin (HbAlc) was mea-sured by high performance liquid chromatography. The expression level of FOSL2 protein was examined by enzyme-linked immunosorbent assay (ELISA). Data was analyzed by SPSS 19.0. Results Compared with the NGT group, BMI [(25.02 ±3.19) vs (28.36 ±4.01), = 0.000], FPG [(5.45 ±0.69) vs (11.4 ±4.39), = 0.000], HbA1c [(6.21 ±1.30) vs (10.20 ±2.10), = 0.000], TC [(3.80 ±0.87) vs (5.16 ±0.87), = 0.000], TG [(1.48 ± 0.85) vs (2.21 ±1.02), = 0.000] and LDL-C [(2.26 ±0.83) vs (2.63 ±0.74), = 0.018] increased; however, HDL-C [(1.19 ±0.30) vs (1.03 ±0.34), = 0.011] and the expression level of FOSL2 protein [(41.48 ±26.32) vs (18.09 ±9.48), = 0.000] decreased in the T2DM group. Compared with the NGT group, FINS [(11.61 ± 0.94) vs (16.13 ±1.61), = 0.017], HOMA-IR [(2.74 ±0.22) vs (7.81 ±0.75), = 0.000] increased in the T2DM group. BMI ( = -0.44, = 0.005), FPG ( = -0.39, = 0.013), HbAlc ( = -0.34, = 0.044) and TC ( = - 0.35, = 0.027) were negatively correlated with the serum level of FOSL2 protein in the Uygur patients with T2DM in Xinjiang. BMI (β= -2.17, = 0.032) was involved in the regression equation which showed that BMI influenced the expression level of FOSL2 protein. Conclusions The lowered expression level of FOSL2 protein may be involved in the occurrence and progression of insulin resistance and T2DM in Uygur in Xin-jiang. BMI is an important factor influencing the expression of FOSL2 protein in T2DM patients of Uygur.关键词
2型糖尿病/维吾尔族/FOS样抗原2Key words
type 2 diabetes mellitus/Uygur/FOS-like antigen 2分类
医药卫生引用本文复制引用
胡颖,李军,李思源,王思瑶,曹国磊,侯俊霞..FOS样抗原2蛋白表达在新疆维吾尔族2型糖尿病中的应用[J].中国现代医学杂志,2016,26(5):26-30,5.基金项目
石河子大学重大科技攻关计划（Nogxjs2012-zdgg02-04）；兵团科技援疆项目(No2014AB049)；兵团中青年科技创新领军人才专项 （No2014AB049）
